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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Lysosomal acid lipase/cholesteryl ester hydrolase
Summary
- UniProt ID
- P38571
- Gene Symbol
-
- LIPA
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011671
- GlyConnect
- GlyGen
- P38571
- PubChem
- P38571
- SwissLipids
- The Human Metabolome Database
- HMDBP00227
- The O-GlcNAc Database
- P38571
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Direct protein sequencing
- Disease variant
- Glycoprotein
- Hydrolase
- Lipid degradation
- Lysosome
- Reference proteome
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| cytosol |
| fibrillar center |
| nucleoplasm |
| lysosomal lumen |
| lysosome |
| intracellular membrane-bounded organelle |
| GO Term |
|---|
| sterol esterase activity |
| lipase activity |
Sequence
MKMRFLGLVVCLVLWTLHSEGSGGKLTAVDPETNMNVSEIISYWGFPSEEYLVETEDGYILCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANSSLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFILNKTGQEQVYYVGHSQGTTIGFIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGRLPDHLIKDLFGDKEFLPQSAFLKWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSRVDVYTTHSPAGTSVQNMLHWSQAVKFQKFQAFDWGSSAKNYFHYNQSYPPTYNVKDMLVPTAVWSGGHDWLADVYDVNILLTQITNLVFHESIPEWEHLDFIWGLDAPWRLYNKIINLMRKYQ
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 36 | N-linked (GlcNAc...) asparagine | |||
| 72 | N-linked (GlcNAc...) asparagine |
|
||
| 101 | N-linked (GlcNAc...) asparagine |
|
||
| 119 |
|
|
||
| 155 |
|
|||
| 161 | N-linked (GlcNAc...) asparagine | |||
| 271 |
|
|
||
| 273 | N-linked (GlcNAc...) asparagine | |||
| 321 | N-linked (GlcNAc...) asparagine | |||
|
|
|
G20991XV
G49108TO
G66088HZ
G70232NH
G03644CB
G47518TP
G93718GY
G57776ZS
G68490OW
G90382BL
G79666IR
G45395BF
G43223CG
G48414YA
G27058EU
G83460ZZ
G08290VR
G46503DX
G70101JE
G80920RR
G29299MO
G62765YT
G62894KT
G11870QZ
G47644PP
G31852PQ
G11314AS
G39188ZX
G41247ZX
G02815KT
G06110VR
G74724QE
G92275SC
G64527OM
G05724UK
G92050GC
G28681TP
G58001LT
G92135MA
G78787DI
G43769HG
G96091TT
G92406TI
G59924QI
G47950XN
G90575OW
G50282JC
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| LDL clearance | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:1168 | familial hyperlipidemia | |
| DOID:11801 | protein-energy malnutrition | |
| DOID:11847 | coronary thrombosis | |
| DOID:11870 | Pick's disease | |
| DOID:12139 | dysthymic disorder | |
| DOID:12239 | anal margin squamous cell carcinoma | |
| DOID:12328 | marasmus | |
| DOID:12450 | pancytopenia | |
| DOID:1287 | cardiovascular system disease | |
| DOID:13250 | diarrhea |
