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Thrombopoietin

Summary

UniProt ID

P40225

Gene Symbol

THPO
MGDF

Organism

Homo sapiens (human)

External Links

GlyConnect

GlyGen

P40225

PubChem

P40225

Annotation

Keyword

3D-structure
Alternative splicing
Cytokine
Disease variant
Disulfide bond
Glycoprotein
Hormone
Reference proteome
Secreted
Signal

Gene Ontology (GO)

Displaying entries **1 - 10** of 12 in total

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GO Term
positive regulation of protein phosphorylation
cell population proliferation
positive regulation of cell population proliferation
megakaryocyte differentiation
megakaryocyte development
positive regulation of megakaryocyte differentiation
positive regulation of hematopoietic stem cell proliferation
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
positive regulation of MAPK cascade
receptor signaling pathway via STAT

Displaying **all 2** entries
GO Term
extracellular region
extracellular space

Displaying **all 4** entries
GO Term
cytokine activity
hormone activity
growth factor activity
signaling receptor binding

Annotation information from UniProt.

Sequence

MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTTAVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSLDQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	PubMed ID	GlyTouCan ID	Source
22	O-linked (GalNAc...) serine	8942648		UniProt GlyGen
58	O-linked (GalNAc...) threonine	8942648		UniProt GlyGen
131	O-linked (GalNAc...) threonine	8942648		UniProt GlyGen
179	O-linked (GalNAc...) threonine	8942648		UniProt GlyGen
180	O-linked (GalNAc...) threonine	8942648		UniProt GlyGen
184	O-linked (GalNAc...) serine	8942648		UniProt GlyGen
197	N-linked (GlcNAc...) (complex) asparagine	8942648	G56501FP G94531EZ G47058MH G14389GM G57789QC G00227RN G01817YC G00800WJ G90352XZ G17689DH G16265MV G44444MB	UniProt GlyGen
206	N-linked (GlcNAc...) (complex) asparagine	8942648		UniProt GlyGen
213	O-linked (GalNAc...) threonine	8942648		UniProt GlyGen
234	N-linked (GlcNAc...) (complex) asparagine	8942648		UniProt GlyGen