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Prostaglandin-H2 D-isomerase

Summary

UniProt ID

P41222

Gene Symbol

PTGDS
PDS

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011676

GlyConnect

GlyGen

P41222

PubChem

P41222

SwissLipids

SLP:000000141

The Human Metabolome Database

HMDBP01576

The O-GlcNAc Database

P41222

O-GlcNAcAtlas

P41222

Annotation

Keyword

3D-structure
Cytoplasm
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Isomerase
Mast cell degranulation
Membrane
Nucleus
Prostaglandin biosynthesis
Reference proteome
Secreted
Signal
Transport

Gene Ontology (GO)

Displaying **all 7** entries
GO Term
gene expression
mast cell degranulation
response to glucocorticoid
negative regulation of male germ cell proliferation
cyclooxygenase pathway
regulation of circadian sleep/wake cycle, sleep
prostaglandin biosynthetic process

Displaying **all 8** entries
GO Term
endoplasmic reticulum membrane
rough endoplasmic reticulum
perinuclear region of cytoplasm
extracellular region
extracellular space
Golgi apparatus
nuclear membrane
extracellular exosome

Displaying **all 3** entries
GO Term
prostaglandin-D synthase activity
retinoid binding
fatty acid binding

Annotation information from UniProt.

Sequence

MATHHTLWMGLALLGVLGDLQAAPEAQVSVQPNFQQDKFLGRWFSAGLASNSSWLREKKAALSMCKSVVAPATDGGLNLTSTFLRKNQCETRTMLLQPAGSLGSYSYRSPHWGSTYSVSVVETDYDQYALLYSQGSKGPGEDFRMATLYSRTQTPRAELKEKFTAFCKAQGFTEDTIVFLPQTDKCMTEQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 9** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
29	O-linked (GalNAc...) serine	23234360	G29931IJ G43417UB	UniProt GlyGen GlyConnect
51	N-linked (GlcNAc...) (complex) asparagine	19159218 19838169 8336134	G12793SR G58598BO G46665ZP G15169WU G39368QD G61806WR G20312EM G80075MS G57776ZS G56087PR G39064KU G86234IN G86795LJ G86880BF G52527GH G28622IK G90382BL G91473PK G90093AU G36013ES G26915XM G79666IR G81263BG G44778BV G34989PA G81198YO G06330RB G50120TH G51413EV G22310AV G45395BF G34423JR G02628JF G66163OV G02030ZB G86632ZU G03984TW G31615DN G15569GG G82830MN G48414YA G99966GV G08110WX G61256FT G72797UR G36167NI G66751BK G72667IM G76295SF G80223IX G07075ND G84452RH G96095QD G82592ZH G22313SX G25520XG G91636VS G75256KV G24835MQ G35253PZ G06601SQ G08290VR G48584BU G09862LV G79568CQ G03382KH G42124LM G23863VK G31118FR G31916IQ G64409MC G14260UH G47644PP G23432EQ G10256JP G95177YH G23719VF G36379GD G92275SC	GlycoProtDB UniProt GlyGen GlyConnect
67			G25278BX G46524LG G85228QD G48584BU G79568CQ G31936TA G94854LT	GlyGen GlyConnect
73			G85228QD G47681UP	GlyGen GlyConnect
78	N-linked (GlcNAc...) (complex) asparagine	16335952 19139490 19838169 22171320 8336134	G48488CO G69834CE G27322BI G66088HZ G39170TE G00433UK G39643OJ G39595FH G69237TO G62461SM G58598BO G64394MX G19603RR G11611PG G67900CJ G46665ZP G76417NN G15169WU G26101XB G79896BV G64227LK G28135GF G57888GL G69521XL G67303LF G92081HT G49084LP G35541EV G34617SM G44173IH G37881RL G41346UA G30799SW G87015RU G46487SG G23133OF G61806WR G20312EM G80075MS G11629QQ G57776ZS G30751OD G56087PR G41882MT G39064KU G31596VW G61053JL G86408JD G13728QT G99668VU G86234IN G60834IK G86795LJ G86880BF G27947YN G87651GX G90382BL G91473PK G90093AU G02315DX G24954UD G18938PT G78502KD G81375TC G36013ES G68833MP G26915XM G87123QX G96577RX G79666IR G81263BG G78701GW G92135MA G26403SG G44778BV G75607BQ G34989PA G81198YO G15488CF G06330RB G40834TG G50120TH G47012YE G51413EV G22310AV G45395BF G88374WZ G59324HL G04672QB G88061BX G52589SM G02628JF G10819WX G66163OV G40926MX G59536GA G14972EH G22625SJ G02030ZB G43223CG G80759CD G86632ZU G64275UO G58954YZ G95977AE G54612UD G31615DN G15569GG G82830MN G12579WK G08918WF G75983OB G00912UN G48414YA G58087IP G49856OX G99966GV G19116TW G56284ZY G08110WX G72797UR G95389BC G70822IO G87661QW G66760KM G83646BJ G36167NI G66751BK G72667IM G76295SF G66621EA G46691LC G80223IX G07075ND G25418HZ G27126ED G66766XF G04657PL G27058EU G84452RH G96095QD G46524LG G44305KR G10773YW G51640FO G82592ZH G20425TQ G36131WL G22313SX G25520XG G41071NU G91636VS G07755XJ G46923KZ G70418MS G24835MQ G86182NS G76613WN G35253PZ G85228QD G46902YN G32259BI G44215PV G06356OH G59626AS G72398FA G84862VB G06601SQ G08290VR G14994KB G19993OB G23294PN G48584BU G70101JE G80920RR G09862LV G79568CQ G03382KH G42124LM G29879MS G23863VK G31118FR G83555HU G77547TA G14260UH G62765YT G64527OM G47644PP G72791KH G10256JP G95177YH G22140GZ G50045TK G05049YU G46283XF G85269DF G95865ZB G31936TA G72787SB G23719VF G11314AS G41247ZX G36379GD G92050GC G92275SC G28681TP	GlycoProtDB UniProt GlyGen GlyConnect
80			G22625SJ G47681UP	GlyGen GlyConnect
81			G49108TO	GlyGen
87			G48414YA	GlyGen GlyConnect
			G49108TO	GlyGen The O-GlcNAc Database GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Homo sapiens
Transcriptional regulation of testis differentiation	Homo sapiens

Human Protein Atlas

ENSG00000107317

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying entries **1 - 10** of **217** in total

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DO ID	Disease Name	Source
DOID:0050127	sinusitis	DisGeNET
DOID:0050589	inflammatory bowel disease	DisGeNET DisGeNET DisGeNET
DOID:0050778	Meckel syndrome	DisGeNET
DOID:0050782	Zollinger-Ellison syndrome	DisGeNET
DOID:0050801	androgenic alopecia	DisGeNET
DOID:0050848	obstructive sleep apnea	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:10155	intestinal cancer	DisGeNET
DOID:0050902	medulloblastoma	DisGeNET DisGeNET DisGeNET
DOID:0060058	lymphoma	DisGeNET

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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International Collaboration

Acknowledgements