GlyCosmos Portal

Annotation

Keyword: 3D-structure Alternative splicing Amino-acid transport Cell membrane Chloride Disease variant Epilepsy Glycoprotein Metal-binding Palmitate Phosphoprotein Potassium Proteomics identification Reference proteome Sodium Symport Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 28 in total

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GO Term	Evidence Code	Reference
glutathione biosynthetic process	IEA	GO_REF
neurotransmitter transport	TAS	Reactome
neurotransmitter transport	IEA	GO_REF
chemical synaptic transmission	TAS	PMID
visual behavior

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

modified amino acid metabolic process [inference]

glutathione metabolic process [inference]

glutathione biosynthetic process

modified amino acid biosynthetic process [inference]

glutathione biosynthetic process

sulfur compound metabolic process [inference]

glutathione metabolic process [inference]

glutathione biosynthetic process

sulfur compound biosynthetic process [inference]

glutathione biosynthetic process

biosynthetic process [inference]

modified amino acid biosynthetic process [inference]

glutathione biosynthetic process

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

sulfur compound biosynthetic process [inference]

glutathione biosynthetic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

cellular response to cocaine

transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

behavior [inference]

multicellular organism growth

developmental process [inference]

anatomical structure development [inference]

animal gross anatomical part developmental process [inference]

telencephalon development

growth [inference]

developmental growth [inference]

multicellular organism growth

response to stimulus [inference]

response to stress [inference]

response to wounding

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior

response to chemical [inference]

response to acid chemical [inference]

response to amino acid

response to xenobiotic stimulus

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

cellular response to cocaine

response to nitrogen compound [inference]

response to alkaloid [inference]

response to cocaine [inference]

cellular response to cocaine

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

response to oxygen-containing compound [inference]

response to cocaine [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

cellular response to cocaine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

cellular response to cocaine

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

neurotransmitter transport

neurotransmitter uptake [inference]

neurotransmitter reuptake

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

acidic amino acid transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

vascular transport [inference]

transport across blood-brain barrier

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

transepithelial transport

nitrogen compound transport [inference]

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

import into cell [inference]

neurotransmitter uptake [inference]

neurotransmitter reuptake

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

establishment of localization in cell [inference]

neurotransmitter reuptake

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

regulation of D-glucose import across plasma membrane [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

regulation of D-glucose import across plasma membrane [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	Reference
plasma membrane	EXP	PMID PMID
plasma membrane	TAS	Reactome Reactome
plasma membrane	IMP	PMID PMID
plasma membrane	IBA	GO_REF
plasma membrane	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex

cellular anatomical structure [inference]

cell surface

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

axolemma

synaptic membrane [inference]

presynaptic membrane

membrane microdomain [inference]

membrane raft

cell junction [inference]

synapse [inference]

glutamatergic synapse

leading edge membrane [inference]

neuron projection membrane [inference]

axolemma

cell projection [inference]

plasma membrane bounded cell projection [inference]

glial cell projection [inference]

astrocyte projection

organelle [inference]

membrane-bounded organelle [inference]

vesicle

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
L-glutamate transmembrane transporter activity	TAS	PMID
L-glutamate transmembrane transporter activity	IDA	PMID
L-glutamate transmembrane transporter activity	IBA	GO_REF
L-glutamate transmembrane transporter activity	IEA	GO_REF GO_REF
high-affinity L-glutamate transmembrane transporter activity	TAS	Reactome Reactome

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

organic acid:sodium symporter activity [inference]

sodium:dicarboxylate symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

organic acid:sodium symporter activity [inference]

sodium:dicarboxylate symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

monoatomic anion transmembrane transporter activity

amino acid transmembrane transporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

acidic amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity

L-cysteine transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

L-cysteine transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

organic acid:sodium symporter activity [inference]

sodium:dicarboxylate symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

carboxylic acid transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

L-cysteine transmembrane transporter activity

dicarboxylic acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

sodium:dicarboxylate symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

L-cysteine transmembrane transporter activity

sulfur compound transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

L-cysteine transmembrane transporter activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYAAHNSVIVDECKVTLAANGKSADCSVEEEPWKREK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
206	N-linked (GlcNAc...) asparagine			UniProt
216	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Astrocytic Glutamate-Glutamine Uptake And Metabolism	Homo sapiens
Glutamate Neurotransmitter Release Cycle	Homo sapiens
SLC-mediated transport of amino acids	Homo sapiens

Human Protein Atlas

ENSG00000110436

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080442	developmental and epileptic encephalopathy 41	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements