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Glucagon-like peptide 1 receptor

Summary

UniProt ID

P43220

Gene Symbol

GLP1R

Gene ID

2740

Organism

Homo sapiens (human)

External Links

GlyGen: P43220
PubChem: P43220
The Human Metabolome Database: HMDBP14647
Re-Glyco: P43220

Annotation

Keyword

3D-structure
ADP-ribosylation
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying **all 2** entries
GO Term
plasma membrane
membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 11 in total

1

2

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GO Term
hormone secretion
activation of adenylate cyclase activity
negative regulation of blood pressure
positive regulation of blood pressure
response to psychosocial stress
adenylate cyclase-activating G protein-coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
post-translational protein targeting to membrane, translocation
cell surface receptor signaling pathway
learning or memory

Displaying **all 4** entries
GO Term
transmembrane signaling receptor activity
glucagon-like peptide 1 receptor activity
glucagon receptor activity
peptide hormone binding

Annotation information from UniProt.

Sequence

MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	Source
63	N-linked (GlcNAc...) asparagine	22412906	UniProt GlyGen
82	N-linked (GlcNAc...) asparagine	22412906	UniProt GlyGen
115	N-linked (GlcNAc...) asparagine	22412906	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
G alpha (s) signalling events	Homo sapiens
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Homo sapiens
Glucagon-type ligand receptors	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9970	obesity	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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External Links

Annotation

International Collaboration

Acknowledgements