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Pro-neuregulin-1, membrane-bound isoform

Summary

UniProt ID

P43322

Gene Symbol

Nrg1
Ndf

Organism

Rattus norvegicus (Norway rat)

External Links

Annotation

Keyword

Alternative splicing
Cell membrane
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Growth factor
Immunoglobulin domain
Reference proteome
Secreted
Transmembrane helix

Gene Ontology (GO)

Displaying entries **51 - 60** of 63 in total

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GO Term
endocardial cell differentiation
positive regulation of cardiac muscle cell differentiation
regulation of presynapse assembly
negative regulation of neuron migration
positive regulation of axon regeneration
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
positive regulation of calcineurin-NFAT signaling cascade
negative regulation of corticosterone secretion
chemorepulsion involved in interneuron migration from the subpallium to the cortex
phosphatidylinositol 3-kinase/protein kinase B signal transduction

Displaying entries **1 - 10** of 12 in total

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GO Term
mossy fiber rosette
postsynaptic density membrane
extracellular space
cytoplasm
plasma membrane
axon
neuromuscular junction
synapse
postsynapse
glutamatergic synapse

Displaying **all 9** entries
GO Term
ErbB-2 class receptor binding
integrin binding
growth factor activity
receptor tyrosine kinase binding
protein tyrosine kinase activator activity
ErbB-3 class receptor binding
chemorepellent activity
receptor ligand activity
transcription coregulator activity

Annotation information from UniProt.

Sequence

MSERKEGRGKGKGKKKDRGSRGKPGPAEGDPSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPENIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEFITGMPASTETAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLIKCAEKEKTFCVNGGECFTVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYMTSRRKRQETEKPLERKLDHSLVKESKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRQKLHDRLRQSLRSERSNLVNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREVETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESVISESNSVIMMSSVENSRHSSPAGGPRGRLHGLGGPRDNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSVAVSPFVEEERPLLLVTPPRLREKKYDHHPQQLNSFHHNPAHQSTSLPPSPLRIVEDEEYETTQEYESVQEPVKKVTNSRRAKRTKPNGHIANRLEMDSNTSSVSSNSESETEDERVGEDTPFLGIQNPLAASLEVAPAFRLAESRTNPAGRFSTQEELQARLSSVIANQDPIAV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
120	N-linked (GlcNAc...) asparagine	UniProt
126	N-linked (GlcNAc...) asparagine	UniProt
164	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 15 in total

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Pathway Name	Organism
Downregulation of ERBB2 signaling	Rattus norvegicus
Downregulation of ERBB2:ERBB3 signaling	Rattus norvegicus
ERBB2 Activates PTK6 Signaling	Rattus norvegicus
ERBB2 Regulates Cell Motility	Rattus norvegicus
GRB2 events in ERBB2 signaling	Rattus norvegicus
GRB7 events in ERBB2 signaling	Rattus norvegicus
PI3K events in ERBB2 signaling	Rattus norvegicus
PI3K events in ERBB4 signaling	Rattus norvegicus
PI3K/AKT Signaling	Rattus norvegicus
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

External Links

Annotation

International Collaboration

Acknowledgements