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Synaptotagmin-1

Summary

UniProt ID

P48018

Gene Symbol

SYT1

Gene ID

281511

Organism

Bos taurus (domestic cattle)

External Links

PubChem: P48018
Re-Glyco: P48018

Annotation

Keyword

Calcium
Calmodulin-binding
Cytoplasm
Cytoplasmic vesicle
Differentiation
Direct protein sequencing
Glycoprotein
Metal-binding
Palmitate
Phosphoprotein
Reference proteome
Repeat
Synapse
Transmembrane helix

Gene Ontology (GO)

Displaying **all 10** entries
GO Term
plasma membrane
axon
dense core granule
Golgi apparatus
clathrin-coated vesicle
synaptic vesicle membrane
presynaptic membrane
exocytic vesicle
chromaffin granule membrane
glutamatergic synapse

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 13 in total

1

2

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GO Term
regulation of synaptic transmission, glutamatergic
regulation of dopamine secretion
vesicle organization
vesicle-mediated transport
cell differentiation
regulation of synaptic vesicle exocytosis
spontaneous neurotransmitter secretion
synchronous neurotransmitter secretion
fast, calcium ion-dependent exocytosis of neurotransmitter
calcium-dependent activation of synaptic vesicle fusion

Displaying **all 8** entries
GO Term
calcium ion binding
calcium ion sensor activity
SNARE binding
calmodulin binding
calcium-dependent phospholipid binding
low-density lipoprotein particle receptor binding
calcium-dependent protein binding
syntaxin-1 binding

Annotation information from UniProt.

Sequence

MVSESHHEALAAPPVTTVATVLPHNATEPASPGEGKEDAFSKLKEKFMNELHKIPLPPWALIAIAIVAVLLVLTCCFCICKKCLFKKKNKKKGKEKGGKNAINMKDVKDLGKTMKDQALKDDDAETGLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVEEEVDAMLAVKK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
25	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 8** entries
Pathway Name	Organism
Acetylcholine Neurotransmitter Release Cycle	Bos taurus
Cargo recognition for clathrin-mediated endocytosis	Bos taurus
Clathrin-mediated endocytosis	Bos taurus
Dopamine Neurotransmitter Release Cycle	Bos taurus
GABA synthesis, release, reuptake and degradation	Bos taurus
Glutamate Neurotransmitter Release Cycle	Bos taurus
Norepinephrine Neurotransmitter Release Cycle	Bos taurus
Serotonin Neurotransmitter Release Cycle	Bos taurus