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MIRAGE
Mannan-binding lectin serine protease 1

Summary
UniProt ID
P48740
Gene Symbol
  • CRARF
  • CRARF1
  • MASP1
  • PRSS5
Gene ID
5648
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011702
GlyConnect
GlyGen
P48740
PubChem
P48740
Re-Glyco
P48740
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Autocatalytic cleavage
  • Calcium
  • Complement activation lectin pathway
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • EGF-like domain
  • Glycoprotein
  • Hydroxylation
  • Metal-binding
  • Reference proteome
  • Repeat
  • Secreted
  • Serine protease
  • Signal
  • Sushi
Gene Ontology (GO)
Displaying all 4 entries
GO Term
extracellular region
extracellular space
nucleoplasm
cytosol
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVWMNKVLGRSLPTCLPVCGLPKFSRKLMARIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHQSLDPEDPTLRDSDLLSPSDFKIILGKHWRLRSDENEQHLGVKHTTLHPQYDPNTFENDVALVELLESPVLNAFVMPICLPEGPQQEGAMVIVSGWGKQFLQRFPETLMEIEIPIVDHSTCQKAYAPLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQWYLVGTVSWGDDCGKKDRYGVYSYIHHNKDWIQRVTGVRN
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 6 entries
Position Description PubMed ID GlyTouCan ID Source
49 N-linked (GlcNAc...) asparagine
178 N-linked (GlcNAc...) (complex) asparagine
385 N-linked (GlcNAc...) (complex) asparagine
407 N-linked (GlcNAc...) asparagine
533 N-linked (GlcNAc) asparagine
599 N-linked (GlcNAc) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 5 entries
Pathway Name Organism
Ficolins bind to repetitive carbohydrate structures on the target cell surface Homo sapiens
Initial triggering of complement Homo sapiens
Lectin pathway of complement activation Homo sapiens
SARS-CoV-2 activates/modulates innate and adaptive immune responses Homo sapiens
Scavenging by Class A Receptors Homo sapiens
Disease
Displaying 1 entry
DO ID Disease Name Source
DOID:0060575 3MC syndrome 1
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025