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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Cyclin-dependent kinase 8
Summary
- UniProt ID
- P49336
- Gene Symbol
-
- CDK8
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P49336
- PubChem
- P49336
- The Human Metabolome Database
- HMDBP01191
- The O-GlcNAc Database
- P49336
- O-GlcNAcAtlas
- P49336
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Activator
- Alternative splicing
- Autism spectrum disorder
- Disease variant
- Intellectual disability
- Nucleus
- Reference proteome
- Repressor
- Serine/threonine-protein kinase
- Transcription regulation
- Gene Ontology (GO)
| GO Term |
|---|
| negative regulation of triglyceride metabolic process |
| protein ubiquitination |
| positive regulation of transcription by RNA polymerase II |
| GO Term |
|---|
| nucleoplasm |
| nucleus |
| nucleolus |
| protein-containing complex |
| cyclin-dependent protein kinase holoenzyme complex |
| CKM complex |
| ubiquitin ligase complex |
| mediator complex |
Sequence
MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 410 |
|
|||
| 411 |
|
|||
| 412 |
|
|||
| 413 |
|
|||
| 419 |
|
|||
| 420 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | Homo sapiens |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | Homo sapiens |
| Generic Transcription Pathway | Homo sapiens |
| MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis | Homo sapiens |
| NOTCH1 Intracellular Domain Regulates Transcription | Homo sapiens |
| PPARA activates gene expression | Homo sapiens |
| RSV-host interactions | Homo sapiens |
| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | Homo sapiens |
| Transcriptional regulation of white adipocyte differentiation | Homo sapiens |
