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Repository for lectin-assisted multimodality data
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Glycogen synthase kinase-3 beta
Summary
- UniProt ID
- P49841
- Gene Symbol
-
- GSK3B
- Gene ID
- 2932
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ADP-ribosylation
- ATP-binding
- Alternative splicing
- Alzheimer disease
- Biological rhythms
- Cell membrane
- Cytoplasm
- Developmental protein
- Diabetes mellitus
- Differentiation
- Glycogen metabolism
- Neurogenesis
- Nucleus
- Palmitate
- Phosphoprotein
- Reference proteome
- Serine/threonine-protein kinase
- Signal transduction inhibitor
- Wnt signaling pathway
- Gene Ontology (GO)
| GO Term |
|---|
| nucleus |
| cytoplasm |
| mitochondrion |
| plasma membrane |
| axon |
| dendrite |
| presynapse |
| postsynapse |
| nucleoplasm |
| cytosol |
| GO Term |
|---|
| tau-protein kinase activity |
| RNA polymerase II-specific DNA-binding transcription factor binding |
| protein serine kinase activity |
| NF-kappaB binding |
| beta-catenin binding |
| protein kinase A catalytic subunit binding |
| tau protein binding |
Sequence
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 7 |
|
|||
| 8 |
|
|||
| 21 |
|
|||
| 38 |
|
|||
| 39 |
|
|||
| 43 |
|
|||
| 55 |
|
|||
| 309 |
|
|||
| 363 |
|
|||
| 364 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| AKT phosphorylates targets in the cytosol | Homo sapiens |
| APC truncation mutants have impaired AXIN binding | Homo sapiens |
| AXIN missense mutants destabilize the destruction complex | Homo sapiens |
| B-WICH complex positively regulates rRNA expression | Homo sapiens |
| Beta-catenin phosphorylation cascade | Homo sapiens |
| CRMPs in Sema3A signaling | Homo sapiens |
| CTNNB1 S33 mutants aren't phosphorylated | Homo sapiens |
| CTNNB1 S37 mutants aren't phosphorylated | Homo sapiens |
| CTNNB1 S45 mutants aren't phosphorylated | Homo sapiens |
| CTNNB1 T41 mutants aren't phosphorylated | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050866 | oral squamous cell carcinoma | |
| DOID:10652 | Alzheimer's disease | |
| DOID:3312 | bipolar disorder | |
| DOID:332 | amyotrophic lateral sclerosis | |
| DOID:5419 | schizophrenia |
