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H(+)/Cl(-) exchange transporter 3

Summary

UniProt ID: P51791
Gene Symbol: Clcn3 Clc3
Gene ID: 12725
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003675
RaftProt: P51791
Re-Glyco: P51791

Annotation

Keyword: 3D-structure ATP-binding Alternative splicing Antiport CBS domain Cell membrane Chloride Cytoplasmic vesicle Endosome Glycoprotein Ion transport Lysosome Reference proteome Repeat Transmembrane helix

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
monoatomic ion transport	ISO	GO_REF
ion transport	ISO	GO_REF
chloride transport	ISO	GO_REF
chloride transport	IEA	GO_REF
phagocytosis, engulfment	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

intercellular transport [inference]

synaptic vesicle lumen acidification

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport [inference]

synaptic vesicle lumen acidification

cellular component organization or biogenesis [inference]

cellular component organization [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis [inference]

negative regulation of cell volume

membrane organization [inference]

membrane invagination [inference]

plasma membrane invagination [inference]

phagocytosis, engulfment

multicellular organismal process [inference]

behavior [inference]

locomotory behavior [inference]

adult locomotory behavior

adult behavior [inference]

adult locomotory behavior

photoreceptor cell maintenance

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis [inference]

negative regulation of cell volume

neuron cellular homeostasis

synaptic vesicle lumen acidification

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport [inference]

synaptic vesicle lumen acidification

monoatomic anion transport [inference]

chloride transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport [inference]

synaptic vesicle lumen acidification

intercellular transport [inference]

synaptic vesicle lumen acidification

inorganic anion transport [inference]

chloride transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport [inference]

synaptic vesicle lumen acidification

establishment of localization in cell [inference]

synaptic vesicle lumen acidification

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of reactive oxygen species biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of reactive oxygen species biosynthetic process

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of reactive oxygen species biosynthetic process

regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of reactive oxygen species biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of reactive oxygen species biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of reactive oxygen species biosynthetic process

regulation of reactive oxygen species metabolic process [inference]

regulation of reactive oxygen species biosynthetic process [inference]

positive regulation of reactive oxygen species biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of reactive oxygen species biosynthetic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of reactive oxygen species biosynthetic process

positive regulation of reactive oxygen species metabolic process [inference]

positive regulation of reactive oxygen species biosynthetic process

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis [inference]

negative regulation of cell volume

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GO Term	Evidence Code	Reference
lysosomal membrane	EXP	PMID
lysosomal membrane	IDA	PMID PMID
lysosomal membrane	IBA	GO_REF
lysosomal membrane	IEA	GO_REF
endosome	IDA	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane

cytoplasmic vesicle membrane [inference]

endosome membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

apical plasma membrane

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

endocytic vesicle [inference]

phagocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

specific granule

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

endocytic vesicle [inference]

phagocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

specific granule

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

endocytic vesicle [inference]

phagocytic vesicle

secretory vesicle [inference]

secretory granule [inference]

specific granule

exocytic vesicle [inference]

synaptic vesicle

neuron projection terminus [inference]

axon terminus

side of membrane [inference]

external side of plasma membrane

presynapse [inference]

axon terminus

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
monoatomic ion channel activity	ISO	GO_REF
ion channel activity	ISO	GO_REF
voltage-gated monoatomic ion channel activity	ISO	GO_REF
voltage-gated chloride channel activity	ISS	GO_REF
voltage-gated chloride channel activity	ISO	GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity

voltage-gated monoatomic ion channel activity

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

monoatomic anion channel activity [inference]

volume-sensitive anion channel activity [inference]

volume-sensitive chloride channel activity

chloride channel activity

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

chloride:proton antiporter activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

volume-sensitive anion channel activity [inference]

volume-sensitive chloride channel activity

chloride channel activity

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity

chloride:proton antiporter activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity

voltage-gated monoatomic ion channel activity

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

monoatomic anion channel activity [inference]

volume-sensitive anion channel activity [inference]

volume-sensitive chloride channel activity

chloride channel activity

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity

voltage-gated monoatomic anion channel activity [inference]

voltage-gated chloride channel activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity

solute:inorganic anion antiporter activity [inference]

chloride:proton antiporter activity

binding [inference]

protein binding [inference]

protein domain specific binding [inference]

PDZ domain binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MESEQLFHRGYYRNSYNSITSASSDEELLDGAGAIMDFQTSEDDNLLDGDTAAGTHYTMTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRPAGVGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRSDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGIVLGIITKKDILRHMAQTANQDPASIMFN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites