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MIRAGE
Sodium-dependent serotonin transporter
Summary
- UniProt ID
- P51905
- Gene Symbol
-
- CG4545
- SerT
- Gene ID
- 37895
- Organism
- Drosophila melanogaster (fruit fly)
Annotation
- Keyword
-
- Cell membrane
- Disulfide bond
- Glycoprotein
- Metal-binding
- Neurotransmitter transport
- Reference proteome
- Sodium
- Symport
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| plasma membrane |
| axon |
| neuron projection |
| synapse |
| axon terminus |
| GO Term |
|---|
| serotonin uptake |
| sodium ion transmembrane transport |
| serotonin transport |
| amino acid transport |
| monoamine transport |
| GO Term |
|---|
| serotonin:sodium:chloride symporter activity |
| monoamine transmembrane transporter activity |
| serotonin binding |
| metal ion binding |
Sequence
MDRSGSSDFAGAAATTGRSNPAPWSDDKESPNNEDDSNEDDGDHTTPAKVTDPLAPKLANNERILVVSVTERTRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGGGAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTIIGWAVYYLFASFTSKLPWTSCDNPWNTENCMQVTSENFTELATSPAKEFFERKVLESYKGNGLDFMGPVKPTLALCVFGVFVLVYFSLWKGVRSAGKVVWVTALAPYVVLIILLVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFFSLGPGFGTLLALSSYNKFNNNCYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFIVYPEAIATMSGSVFWSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRRRELFVLLLLAFIFLCALPTMTYGGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRICWTYISPVFLLTIFIFSIMGYKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFASKGGCRQRLQESFQPEDNCGSVVPGQQGTSV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 211 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Clearance of seratonin | Drosophila melanogaster |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:14320 | generalized anxiety disorder | |
| DOID:1596 | depressive disorder |
