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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Alpha-N-acetylglucosaminidase
Summary
- UniProt ID
- P54802
- Gene Symbol
-
- NAGLU
- UFHSD1
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0011738
- GlyConnect
- GlyGen
- P54802
- PubChem
- P54802
- The Human Metabolome Database
- HMDBP01596
- The O-GlcNAc Database
- P54802
Annotation
- Keyword
-
- 3D-structure
- Charcot-Marie-Tooth disease
- Direct protein sequencing
- Disease variant
- Glycoprotein
- Glycosidase
- Lysosome
- Mucopolysaccharidosis
- Neurodegeneration
- Reference proteome
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| lysosomal lumen |
| extracellular exosome |
| lysosome |
| GO Term |
|---|
| alpha-N-acetylglucosaminidase activity |
Sequence
MEAVAVAAAVGVLLLAGAGGAAGDEAREAAAVRALVARLLGPGPAADFSVSVERALAAKPGLDTYSLGGGGAARVRVRGSTGVAAAAGLHRYLRDFCGCHVAWSGSQLRLPRPLPAVPGELTEATPNRYRYYQNVCTQSYSFVWWDWARWEREIDWMALNGINLALAWSGQEAIWQRVYLALGLTQAEINEFFTGPAFLAWGRMGNLHTWDGPLPPSWHIKQLYLQHRVLDQMRSFGMTPVLPAFAGHVPEAVTRVFPQVNVTKMGSWGHFNCSYSCSFLLAPEDPIFPIIGSLFLRELIKEFGTDHIYGADTFNEMQPPSSEPSYLAAATTAVYEAMTAVDTEAVWLLQGWLFQHQPQFWGPAQIRAVLGAVPRGRLLVLDLFAESQPVYTRTASFQGQPFIWCMLHNFGGNHGLFGALEAVNGGPEAARLFPNSTMVGTGMAPEGISQNEVVYSLMAELGWRKDPVPDLAAWVTSFAARRYGVSHPDAGAAWRLLLRSVYNCSGEACRGHNRSPLVRRPSLQMNTSIWYNRSDVFEAWRLLLTSAPSLATSPAFRYDLLDLTRQAVQELVSLYYEEARSAYLSKELASLLRAGGVLAYELLPALDEVLASDSRFLLGSWLEQARAAAVSEAEADFYEQNSRYQLTLWGPEGNILDYANKQLAGLVANYYTPRWRLFLEALVDSVAQGIPFQQHQFDKNVFQLEQAFVLSKQRYPSQPRGDTVDLAKKIFLKYYPRWVAGSW
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 134 |
|
|||
| 261 | N-linked (GlcNAc...) asparagine |
|
||
| 272 | N-linked (GlcNAc...) asparagine |
|
||
| 435 | N-linked (GlcNAc...) asparagine | |||
| 503 | N-linked (GlcNAc...) asparagine |
|
||
| 526 | N-linked (GlcNAc...) asparagine | |||
| 532 | N-linked (GlcNAc...) asparagine | |||
|
|
G84452RH
G64394MX
G52527GH
G56784JY
G34989PA
G47012YE
G45395BF
G14972EH
G43223CG
G40574BA
G08918WF
G75983OB
G00912UN
G66621EA
G25418HZ
G66766XF
G51653BI
G83460ZZ
G72398FA
G20210JR
G23294PN
G48584BU
G80920RR
G84820NF
G12313PD
G82463GQ
G14260UH
G62765YT
G62894KT
G11870QZ
G31852PQ
G39188ZX
G41247ZX
G02815KT
G74724QE
G92275SC
G84225JN
G48414YA
G06356OH
G59626AS
G41071NU
G46503DX
G70101JE
G65184UU
G42124LM
G02886BB
G64527OM
G72790NZ
G10486CT
G05049YU
G55383ZG
G72291OX
G95865ZB
G05724UK
G49955PK
G72787SB
G11314AS
G35029YA
G23453IV
G57776ZU
G06110VR
G92050GC
G14669DU
G28681TP
G58001LT
G10019LZ
G38663NM
G37881RL
G22310AV
G26330YA
G46691LC
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| HS-GAG degradation | Homo sapiens |
| MPS IIIB - Sanfilippo syndrome B | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0110178 | Charcot-Marie-Tooth disease axonal type 2V | |
| DOID:0110307 | hypertrophic cardiomyopathy 1 | |
| DOID:0111044 | gray platelet syndrome | |
| DOID:0111049 | platelet-type bleeding disorder 17 | |
| DOID:0111051 | platelet-type bleeding disorder 18 | |
| DOID:0111390 | mucopolysaccharidosis Ih | |
| DOID:0111391 | mucopolysaccharidosis IVA | |
| DOID:0111393 | mucopolysaccharidosis type IIIC | |
| DOID:0111394 | mucopolysaccharidosis type IIIB | |
| DOID:0111395 | mucopolysaccharidosis type IIIA |
