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MIRAGE
DNA polymerase epsilon subunit 2

Summary
UniProt ID
P56282
Gene Symbol
  • DPE2
  • POLE2
Gene ID
5427
Organism
Homo sapiens (human)
PubChem
P56282
The Human Metabolome Database
HMDBP00970
The O-GlcNAc Database
P56282
Re-Glyco
P56282
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • DNA replication
  • DNA-binding
  • Nucleus
  • Reference proteome
Gene Ontology (GO)
Displaying all 4 entries
GO Term
nuclear body
epsilon DNA polymerase complex
intracellular membrane-bounded organelle
nucleoplasm
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying all 2 entries
GO Term
DNA binding
DNA-directed DNA polymerase activity
Annotation information from UniProt.
Sequence
MAPERLRSRALSAFKLRGLLLRGEAIKYLTEALQSISELELEDKLEKIINAVEKQPLSSNMIERSVVEAAVQECSQSVDETIEHVFNIIGAFDIPRFVYNSERKKFLPLLMTNHPAPNLFGTPRDKAEMFRERYTILHQRTHRHELFTPPVIGSHPDESGSKFQLKTIETLLGSTTKIGDAIVLGMITQLKEGKFFLEDPTGTVQLDLSKAQFHSGLYTEACFVLAEGWFEDQVFHVNAFGFPPTEPSSTTRAYYGNINFFGGPSNTSVKTSAKLKQLEEENKDAMFVFLSDVWLDQVEVLEKLRIMFAGYSPAPPTCFILCGNFSSAPYGKNQVQALKDSLKTLADIICEYPDIHQSSRFVFVPGPEDPGFGSILPRPPLAESITNEFRQRVPFSVFTTNPCRIQYCTQEITVFREDLVNKMCRNCVRFPSSNLAIPNHFVKTILSQGHLTPLPLYVCPVYWAYDYALRVYPVPDLLVIADKYDPFTTTNTECLCINPGSFPRSGFSFKVFYPSNKTVEDSKLQGF
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying 1 entry
Position Description PubMed ID GlyTouCan ID Source
174
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 10 entries
Pathway Name Organism
Activation of the pre-replicative complex Homo sapiens
DNA replication initiation Homo sapiens
Dual Incision in GG-NER Homo sapiens
Dual incision in TC-NER Homo sapiens
Gap-filling DNA repair synthesis and ligation in GG-NER Homo sapiens
Gap-filling DNA repair synthesis and ligation in TC-NER Homo sapiens
HDR through Homologous Recombination (HRR) Homo sapiens
PCNA-Dependent Long Patch Base Excision Repair Homo sapiens
Recognition of DNA damage by PCNA-containing replication complex Homo sapiens
Termination of translesion DNA synthesis Homo sapiens
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025