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Protein smoothened
Summary
- UniProt ID
- P56726
- Gene Symbol
-
- Smo
- Smoh
- Gene ID
- 319757
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- 3D-structure
- Cell membrane
- Cell projection
- Developmental protein
- Disulfide bond
- G-protein coupled receptor
- Glycoprotein
- Phosphoprotein
- Reference proteome
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| cytoplasm |
| late endosome |
| endoplasmic reticulum |
| endoplasmic reticulum-Golgi intermediate compartment |
| Golgi apparatus |
| centriole |
| caveola |
| endocytic vesicle membrane |
| plasma membrane |
| cilium |
Sequence
MAAGRPVRGPELAPRRLLQLLLLVLLGGPGRGAALSGNVTGPGPHSASGSSRRDVPVTSPPPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPEGCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANMWLVEAEISPELEKRLGRKKKRRKRKKEVCPLRPAPELHHSAPVPATSAVPRLPQLPRQKCLVAANAWGTGESCRQGAWTLVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTNLMEAEILDADSDF
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of SMO | Mus musculus |
| BBSome-mediated cargo-targeting to cilium | Mus musculus |
| Hedgehog 'off' state | Mus musculus |
| Hedgehog 'on' state | Mus musculus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050902 | medulloblastoma | |
| DOID:9675 | pulmonary emphysema |
