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Beta-secretase 1

Summary

UniProt ID

P56818

Gene Symbol

Bace1
Bace

Organism

Mus musculus (house mouse)

External Links

GlyGen: P56818
PubChem: P56818

Annotation

Keyword

Acetylation
Aspartyl protease
Cell membrane
Cell projection
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Isopeptide bond
Lysosome
Palmitate
Phosphoprotein
Reference proteome
Signal
Transmembrane helix
Ubl conjugation
Zymogen

Gene Ontology (GO)

Displaying entries **1 - 10** of 17 in total

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GO Term
positive regulation of neuron apoptotic process
modulation of chemical synaptic transmission
detection of mechanical stimulus involved in sensory perception of pain
presynaptic modulation of chemical synaptic transmission
signaling receptor ligand precursor processing
prepulse inhibition
regulation of synaptic plasticity
membrane protein ectodomain proteolysis
response to lead ion
amyloid-beta formation

Displaying entries **11 - 20** of 21 in total

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GO Term
trans-Golgi network
synaptic vesicle
lysosome
Golgi apparatus
plasma membrane
membrane
axon
cytoplasmic vesicle
cell surface
recycling endosome

Displaying **all 5** entries
GO Term
endopeptidase activity
amyloid-beta binding
aspartic-type endopeptidase activity
peptidase activity
enzyme binding

Annotation information from UniProt.

Sequence

MAPALHWLLLWVGSGMLPAQGTHLGIRLPLRSGLAGPPLGLRLPRETDEESEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAGFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
153	N-linked (GlcNAc...) asparagine	26467158	G08539HC	UniProt GlyGen
172	N-linked (GlcNAc...) asparagine	26467158		UniProt GlyGen
223	N-linked (GlcNAc...) asparagine	26467158		UniProt GlyGen
354	N-linked (GlcNAc...) asparagine	26467158		UniProt GlyGen