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Nicastrin

Summary

UniProt ID

P57716

Gene Symbol

Ncstn

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0003716

GlyConnect

2562

GlyGen

P57716

PubChem

P57716

The O-GlcNAc Database

P57716

RaftProt

P57716

Annotation

Keyword

Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Notch signaling pathway
Reference proteome
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 10** of 25 in total

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GO Term
regulation of long-term synaptic potentiation
short-term synaptic potentiation
neuron apoptotic process
cellular response to calcium ion
membrane protein intracellular domain proteolysis
amyloid precursor protein metabolic process
amyloid precursor protein biosynthetic process
positive regulation of amyloid precursor protein biosynthetic process
dopamine receptor signaling pathway
Notch signaling pathway

Displaying entries **1 - 10** of 17 in total

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GO Term
Golgi membrane
lysosome
lysosomal membrane
Golgi apparatus
plasma membrane
membrane
protein-containing complex
melanosome
cytoplasmic vesicle membrane
gamma-secretase complex

Displaying **all 4** entries
GO Term
peptidase activity
growth factor receptor binding
ATPase binding
protein-macromolecule adaptor activity

Annotation information from UniProt.

Sequence

MATTRGGSGPDPGSRGLLLLSFSVVLAGLCGGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLKWVLTDGPNPPYMVLLEGKLFTRDVMEKLKGTTSRIAGLAVTLAKPNSTSSFSPSVQCPNDGFGIYSNSYGPEFAHCKKTLWNELGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLGQNGSAPSFPLCAMQLFSHMHAVISTATCMRRSFIQSTFSINPEIVCDPLSDYNVWSMLKPINTSVGLEPDVRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALHKAPDVTTLSRNVMFVFFQGETFDYIGSSRMVYDMENGKFPVRLENIDSFVELGQVALRTSLDLWMHTDPMSQKNESVKNQVEDLLATLEKSGAGVPEVVLRRLAQSQALPPSSLQRFLRARNISGVVLADHSGSFHNRYYQSIYDTAENINVTYPEWQSPEEDLNFVTDTAKALANVATVLARALYELAGGTNFSSSIQADPQTVTRLLYGFLVRANNSWFQSILKHDLRSYLDDRPLQHYIAVSSPTNTTYVVQYALANLTGKATNLTREQCQDPSKVPNESKDLYEYSWVQGPWNSNRTERLPQCVRSTVRLARALSPAFELSQWSSTEYSTWAESRWKDIQARIFLIASKELEFITLIVGFSTLVFSLIVTYCINAKADVLFVAPREPGAVSY

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 17 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
44	N-linked (GlcNAc...) asparagine		G70101JE G80920RR G64527OM G05724UK	GlycoProtDB UniProt GlyGen GlyConnect
54	N-linked (GlcNAc...) asparagine		G70101JE G14260UH G64527OM G41247ZX	GlycoProtDB UniProt GlyGen GlyConnect
128	N-linked (GlcNAc...) asparagine		G14260UH G29375NL	GlycoProtDB UniProt GlyGen GlyConnect
186	N-linked (GlcNAc...) asparagine	19349973		UniProt GlyGen
203	N-linked (GlcNAc...) asparagine			GlycoProtDB UniProt GlyGen
263	N-linked (GlcNAc...) asparagine	19349973	G80920RR	GlycoProtDB UniProt GlyGen
386	N-linked (GlcNAc...) asparagine	19349973	G80920RR G06110VR	GlycoProtDB UniProt GlyGen GlyConnect
434	N-linked (GlcNAc...) asparagine		G48584BU G70101JE G62765YT G64527OM G05724UK G39188ZX G06110VR G66538GV	GlycoProtDB UniProt GlyGen GlyConnect
463	N-linked (GlcNAc...) asparagine			UniProt GlyGen
505	N-linked (GlcNAc...) asparagine	19349973	G49755GI	GlycoProtDB UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
EPH-ephrin mediated repulsion of cells	Mus musculus
NOTCH3 Activation and Transmission of Signal to the Nucleus	Mus musculus
NRIF signals cell death from the nucleus	Mus musculus
Neutrophil degranulation	Mus musculus
Noncanonical activation of NOTCH3	Mus musculus
Nuclear signaling by ERBB4	Mus musculus
Regulated proteolysis of p75NTR	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements