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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Gasdermin-D
Summary
- UniProt ID
- P57764
- Gene Symbol
-
- GSDMD
- DFNA5L
- GSDMDC1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Cell membrane
- Direct protein sequencing
- Glycoprotein
- Inflammasome
- Inflammatory response
- Innate immunity
- Lipid-binding
- Mitochondrion
- Necrosis
- Nucleus
- Palmitate
- Phosphoprotein
- Reference proteome
- Secreted
- Transcription regulation
- Transmembrane beta strand
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| protein homooligomerization |
| pyroptosis |
| GO Term |
|---|
| tertiary granule lumen |
Sequence
MGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKKQRTFQPPATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTDGVPAEGAFTEDFQGLRAEVETISKELELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLGPVEPLDGPAGAVLECLVLSSGMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLLEQSAPWQERSTMSLPPGLLGNSWGEGAPAWVLLDECGLELGEDTPHVCWEPQAQGRMCALYASLALLSGLSQEPH
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 338 | O-linked (GlcNAc) serine |
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Interleukin-1 processing | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
| Purinergic signaling in leishmaniasis infection | Homo sapiens |
| Pyroptosis | Homo sapiens |
| Regulation of TLR by endogenous ligand | Homo sapiens |
| Release of apoptotic factors from the mitochondria | Homo sapiens |
