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Toll-like receptor 8

Summary

UniProt ID

P58682

Gene Symbol

Tlr8

Organism

Mus musculus (house mouse)

External Links

GlyGen: P58682
PubChem: P58682
O-GlcNAcAtlas: P58682

Annotation

Keyword

Disulfide bond
Endosome
Glycoprotein
Inflammatory response
Innate immunity
Leucine-rich repeat
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 16 in total

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GO Term
regulation of protein phosphorylation
inflammatory response
innate immune response
positive regulation of innate immune response
positive regulation of type II interferon production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
canonical NF-kappaB signal transduction
toll-like receptor signaling pathway

Displaying **all 3** entries
GO Term
plasma membrane
endosome membrane
external side of plasma membrane

Displaying **all 4** entries
GO Term
DNA binding
pattern recognition receptor activity
double-stranded RNA binding
single-stranded RNA binding

Annotation information from UniProt.

Sequence

MENMPPQSWILTCFCLLSSGTSAIFHKANYSRSYPCDEIRHNSLVIAECNHRQLHEVPQTIGKYVTNIDLSDNAITHITKESFQKLQNLTKIDLNHNAKQQHPNENKNGMNITEGALLSLRNLTVLLLEDNQLYTIPAGLPESLKELSLIQNNIFQVTKNNTFGLRNLERLYLGWNCYFKCNQTFKVEDGAFKNLIHLKVLSLSFNNLFYVPPKLPSSLRKLFLSNAKIMNITQEDFKGLENLTLLDLSGNCPRCYNAPFPCTPCKENSSIHIHPLAFQSLTQLLYLNLSSTSLRTIPSTWFENLSNLKELHLEFNYLVQEIASGAFLTKLPSLQILDLSFNFQYKEYLQFINISSNFSKLRSLKKLHLRGYVFRELKKKHFEHLQSLPNLATINLGINFIEKIDFKAFQNFSKLDVIYLSGNRIASVLDGTDYSSWRNRLRKPLSTDDDEFDPHVNFYHSTKPLIKPQCTAYGKALDLSLNNIFIIGKSQFEGFQDIACLNLSFNANTQVFNGTEFSSMPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHNAHYFSIAGVTHRLGFIQNLINLRVLNLSHNGIYTLTEESELKSISLKELVFSGNRLDRLWNANDGKYWSIFKSLQNLIRLDLSYNNLQQIPNGAFLNLPQSLQELLISGNKLRFFNWTLLQYFPHLHLLDLSRNELYFLPNCLSKFAHSLETLLLSHNHFSHLPSGFLSEARNLVHLDLSFNTIKMINKSSLQTKMKTNLSILELHGNYFDCTCDISDFRSWLDENLNITIPKLVNVICSNPGDQKSKSIMSLDLTTCVSDTTAAVLFFLTFLTTSMVMLAALVHHLFYWDVWFIYHMCSAKLKGYRTSSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESEDKSVLLCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQYSQYLRLRQRICKSSILQWPNNPKAENLFWQSLKNVVLTENDSRYDDLYIDSIRQY

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **11 - 20** of 22 in total

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Position	Description	GlyTouCan ID	Source
288	N-linked (GlcNAc...) asparagine		UniProt GlyGen
304	N-linked (GlcNAc...) asparagine		UniProt GlyGen
353	N-linked (GlcNAc...) asparagine		UniProt GlyGen
357	N-linked (GlcNAc...) asparagine		UniProt GlyGen
411	N-linked (GlcNAc...) asparagine		UniProt GlyGen
502	N-linked (GlcNAc...) asparagine		UniProt GlyGen
513	N-linked (GlcNAc...) asparagine		UniProt GlyGen
581	N-linked (GlcNAc...) asparagine	G80920RR	UniProt GlyGen
671	N-linked (GlcNAc...) asparagine		UniProt GlyGen
743	N-linked (GlcNAc...) asparagine		UniProt GlyGen