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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Ribose-phosphate pyrophosphokinase 1
Summary
- UniProt ID
- P60891
- Gene Symbol
-
- PRPS1
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P60891
- PubChem
- P60891
- The Human Metabolome Database
- HMDBP00628
- The O-GlcNAc Database
- P60891
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Charcot-Marie-Tooth disease
- Direct protein sequencing
- Disease variant
- Gout
- Intellectual disability
- Kinase
- Magnesium
- Metal-binding
- Neurodegeneration
- Non-syndromic deafness
- Nucleotide biosynthesis
- Reference proteome
- Retinitis pigmentosa
- Gene Ontology (GO)
| GO Term |
|---|
| cytosol |
| ribose phosphate diphosphokinase complex |
| cytoplasm |
| GO Term |
|---|
| protein homodimerization activity |
| ribose phosphate diphosphokinase activity |
| magnesium ion binding |
| ATP binding |
| kinase activity |
| identical protein binding |
Sequence
MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 83 |
|
|||
| 166 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| PRPP biosynthesis | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0014667 | disease of metabolism | |
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | |
| DOID:0050542 | Charcot-Marie-Tooth disease type X | |
| DOID:0050566 | X-linked nonsyndromic deafness | |
| DOID:0050647 | Arts syndrome | |
| DOID:0060249 | scoliosis | |
| DOID:0060600 | obsolete hereditary motor and sensory neuropathy with agenesis of the corpus callosum | |
| DOID:0060843 | hereditary neuropathy with liability to pressure palsies | |
| DOID:0070161 | hereditary sensory and autonomic neuropathy type 2 | |
| DOID:0080144 | childhood acute lymphocytic leukemia |
