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Nitric oxide synthase 3
Summary
- UniProt ID
- P70313
- Gene Symbol
-
- Ecnos
- Nos3
- Gene ID
- 18127
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- Calcium
- Calmodulin-binding
- Cell membrane
- Cytoskeleton
- FAD
- FMN
- Golgi apparatus
- Heme
- Myristate
- NADP
- Oxidoreductase
- Palmitate
- Phosphoprotein
- Reference proteome
- Zinc
- Gene Ontology (GO)
| GO Term |
|---|
| nucleus |
| cytoplasm |
| cytoskeleton |
| Golgi apparatus |
| caveola |
| GO Term |
|---|
| NADP binding |
| metal ion binding |
| nitric-oxide synthase activity |
| tetrahydrobiopterin binding |
| arginine binding |
| actin monomer binding |
| calmodulin binding |
| FMN binding |
| heme binding |
| flavin adenine dinucleotide binding |
Sequence
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSQAPAPPSPTRPAPDHSPPLTRPPDGPRFPRVKNWEVGSITYDTLSAQAQQDGPCTSRRCLGSLVFPRKLQSRPTQGPSPTEQLLGQARDFINQYYNSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRTAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDFRIWNSQLIRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPELFTLPPEMVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSSEIGMRDLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWKGSAAKGAGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAARDIFSPKRSWKRQRYRLSTQAESLQLLPGLTHVHRRKMFQATILSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPPSTEPVAVEQLEKGSPGGPPPGWVRDPRLPPCTLRQALTYFLDITSPPSPRLLRLLSTLAEESSEQQELEALSQDPRRYEEWKWFSCPTLLEVLEQFPSVALPAPLILTQLPLLQPRYYSVSSAPSAHPGEIHLTIAVLAYRTQDGLGPLHYGVCSTWMSQLKAGDPVPCFIRGAPSFRLPPDPNLPCILVGPGTGIAPFRGFWQDRLHDIEIKGLQPAPMTLVFGCRCSQLDHLYRDEVLDAQQRGVFGQVLTAFSRDPGSPKTYVQDLLRTELAAEVHRVLCLEQGHMFVCGDVTMATSVLQTVQRILATEGGMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWSFDPPGPEIPGS
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 119 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Extra-nuclear estrogen signaling | Mus musculus |
| High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells | Mus musculus |
| NOSIP mediated eNOS trafficking | Mus musculus |
| NOSTRIN mediated eNOS trafficking | Mus musculus |
| Nitric oxide stimulates guanylate cyclase | Mus musculus |
| ROS and RNS production in phagocytes | Mus musculus |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | Mus musculus |
| VEGFR2 mediated vascular permeability | Mus musculus |
| eNOS activation | Mus musculus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:10825 | essential hypertension | |
| DOID:13042 | persistent fetal circulation syndrome | |
| DOID:62 | aortic valve disease |
