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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Disintegrin and metalloproteinase domain-containing protein 17
Summary
- UniProt ID
- P78536
- Gene Symbol
-
- ADAM17
- CSVP
- TACE
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Cleavage on pair of basic residues
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Metal-binding
- Metalloprotease
- Notch signaling pathway
- Phosphoprotein
- Reference proteome
- SH3-binding
- Signal
- Transmembrane helix
- Zinc
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| Golgi membrane |
| endoplasmic reticulum lumen |
| cytosol |
| cell surface |
| apical plasma membrane |
| plasma membrane |
| actin cytoskeleton |
| membrane |
| membrane raft |
| cytoplasm |
| GO Term |
|---|
| Notch binding |
| metal ion binding |
| endopeptidase activity |
| metalloendopeptidase activity |
| integrin binding |
| peptidase activity |
| metallopeptidase activity |
| SH3 domain binding |
| cytokine binding |
| interleukin-6 receptor binding |
Sequence
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 103 | N-linked (GlcNAc...) asparagine | |||
| 105 |
|
|||
| 108 |
|
|||
| 157 | N-linked (GlcNAc...) asparagine | |||
| 174 | N-linked (GlcNAc...) asparagine | |||
| 264 | N-linked (GlcNAc...) asparagine | |||
| 265 |
|
|||
| 452 | N-linked (GlcNAc...) asparagine | |||
| 498 | N-linked (GlcNAc...) asparagine | |||
| 539 | N-linked (GlcNAc...) asparagine |
G29184RN
G80920RR
G62765YT
G31852PQ
G41247ZX
G49108TO
G80075MS
G57776ZS
G86880BF
G87123QX
G79666IR
G45395BF
G10819WX
G70441OD
G25079LO
G70101JE
G90659AW
G29299MO
G27058EU
G37399XV
G82463GQ
G14260UH
G83633GK
G64527OM
G28541PG
G39188ZX
G02815KT
G40926MX
G00912UN
G60033FS
G59626AS
G20210JR
G23294PN
G10486CT
G18647XP
G86182NS
G99668VU
G95133RI
G86795LJ
G27947YN
G96577RX
G81263BG
G66163OV
G59536GA
G08918WF
G04657PL
G43769HG
G20425TQ
G46902YN
G44215PV
G70619PT
G06356OH
G65184UU
G72790NZ
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activated NOTCH1 Transmits Signal to the Nucleus | Homo sapiens |
| CD163 mediating an anti-inflammatory response | Homo sapiens |
| Collagen degradation | Homo sapiens |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | Homo sapiens |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | Homo sapiens |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | Homo sapiens |
| Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | Homo sapiens |
| Growth hormone receptor signaling | Homo sapiens |
| Nuclear signaling by ERBB4 | Homo sapiens |
| Regulated proteolysis of p75NTR | Homo sapiens |
