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Standards Ontologies Notations
Disintegrin and metalloproteinase domain-containing protein 17

Summary
UniProt ID
P78536
Gene Symbol
  • ADAM17
  • CSVP
  • TACE
Organism
Homo sapiens (human)
External Links
GlycoProtDB
GPDB0011762
GlyConnect
GlyGen
P78536
PubChem
P78536
The O-GlcNAc Database
P78536
O-GlcNAcAtlas
P78536
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Cleavage on pair of basic residues
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • Metal-binding
  • Metalloprotease
  • Notch signaling pathway
  • Phosphoprotein
  • Reference proteome
  • SH3-binding
  • Signal
  • Transmembrane helix
  • Zinc
  • Zymogen
Gene Ontology (GO)
Annotation information from UniProt.
Sequence
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying entries 1 - 10 of 13 in total
Position Description PubMed ID GlyTouCan ID Source
103 N-linked (GlcNAc...) asparagine
105
108
157 N-linked (GlcNAc...) asparagine
174 N-linked (GlcNAc...) asparagine
264 N-linked (GlcNAc...) asparagine
265
452 N-linked (GlcNAc...) asparagine
498 N-linked (GlcNAc...) asparagine
539 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 13 in total
Pathway Name Organism
Activated NOTCH1 Transmits Signal to the Nucleus Homo sapiens
CD163 mediating an anti-inflammatory response Homo sapiens
Collagen degradation Homo sapiens
Constitutive Signaling by NOTCH1 HD Domain Mutants Homo sapiens
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Homo sapiens
Constitutive Signaling by NOTCH1 PEST Domain Mutants Homo sapiens
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Homo sapiens
Growth hormone receptor signaling Homo sapiens
Nuclear signaling by ERBB4 Homo sapiens
Regulated proteolysis of p75NTR Homo sapiens
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024