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Phosphate-regulating neutral endopeptidase PHEX

Summary

UniProt ID

P78562

Gene Symbol

PHEX
PEX

Organism

Homo sapiens (human)

External Links

GlyGen: P78562
The Human Metabolome Database: HMDBP01807

Annotation

Keyword

Biomineralization
Cell membrane
Disease variant
Disulfide bond
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Gene Ontology (GO)

Displaying entries **1 - 10** of 15 in total

1

2

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GO Term
bone development
response to growth hormone
response to insulin-like growth factor stimulus
organophosphate metabolic process
cellular response to vitamin D
cellular response to parathyroid hormone stimulus
response to sodium phosphate
skeletal system development
proteolysis
cell-cell signaling

Displaying **all 4** entries
GO Term
endoplasmic reticulum
Golgi apparatus
plasma membrane
perinuclear region of cytoplasm

Displaying **all 2** entries
GO Term
metalloendopeptidase activity
zinc ion binding

Annotation information from UniProt.

Sequence

MEAETGSSVETGKKANRGTRIALVVFVGGTLVLGTILFLVSQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCRLW

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 8** entries
Position	Description	GlyTouCan ID	Source
71	N-linked (GlcNAc...) asparagine		UniProt GlyGen
238	N-linked (GlcNAc...) asparagine		UniProt GlyGen
263	N-linked (GlcNAc...) asparagine		UniProt GlyGen
290	N-linked (GlcNAc...) asparagine		UniProt GlyGen
301	N-linked (GlcNAc...) asparagine		UniProt GlyGen
377	N-linked (GlcNAc...) asparagine		UniProt GlyGen
484	N-linked (GlcNAc...) asparagine	G30248BL G80479JV	UniProt GlyGen
736	N-linked (GlcNAc...) asparagine		UniProt GlyGen