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HLA class II histocompatibility antigen, DR beta 3 chain

Summary

UniProt ID

P79483

Gene Symbol

HLA-DRB3

Gene ID

3125

Organism

Homo sapiens (human)

External Links

GlyConnect

HLA class II histocompatibility antigen, DR beta 3 chain

GlyGen

P79483

PubChem

P79483

Re-Glyco

P79483

Annotation

Keyword

3D-structure
Cell membrane
Cytoplasmic vesicle
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Lysosome
MHC II
Reference proteome
Signal
Transmembrane helix
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 13 in total

1

2

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GO Term
MHC class II protein complex
Golgi membrane
lysosomal membrane
ER to Golgi transport vesicle membrane
endocytic vesicle membrane
late endosome membrane
clathrin-coated endocytic vesicle membrane
autolysosome membrane
transport vesicle membrane
lumenal side of endoplasmic reticulum membrane

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying **all 10** entries
GO Term
positive regulation of immune response
positive regulation of T cell activation
myeloid dendritic cell antigen processing and presentation
peptide antigen assembly with MHC class II protein complex
positive regulation of T cell mediated immune response to tumor cell
positive regulation of CD4-positive, alpha-beta T cell activation
T cell receptor signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class II
adaptive immune response
signal transduction

Displaying **all 3** entries
GO Term
MHC class II protein complex binding
MHC class II receptor activity
peptide antigen binding

Annotation information from UniProt.

Sequence

MVCLKLPGGSSLAALTVTLMVLSSRLAFAGDTRPRFLELRKSECHFFNGTERVRYLDRYFHNQEEFLRFDSDVGEYRAVTELGRPVAESWNSQKDLLEQKRGRVDNYCRHNYGVGESFTVQRRVHPQVTVYPAKTQPLQHHNLLVCSVSGFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSALTVEWRARSESAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
48	N-linked (GlcNAc...) asparagine	18697946	G84452RH G80920RR G62765YT G47644PP G31852PQ	UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
Downstream TCR signaling	Homo sapiens
Generation of second messenger molecules	Homo sapiens
Interferon gamma signaling	Homo sapiens
MHC class II antigen presentation	Homo sapiens
PD-1 signaling	Homo sapiens
Phosphorylation of CD3 and TCR zeta chains	Homo sapiens
Translocation of ZAP-70 to Immunological synapse	Homo sapiens

Disease

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080822	aspirin-induced respiratory disease	Alliance of Genome Resources
DOID:12361	Graves' disease	Alliance of Genome Resources
DOID:2377	multiple sclerosis	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements