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DNA ligase 3

Summary

UniProt ID: P97386
Gene Symbol: Lig3
Gene ID
Organism: Mus musculus (house mouse)

External Links

PubChem: P97386
The O-GlcNAc Database: P97386
Re-Glyco: P97386

Annotation

Keyword: ATP-binding Alternative splicing Cell division DNA recombination DNA repair DNA replication Ligase Magnesium Nucleus Phosphoprotein Reference proteome Zinc-finger

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	Reference
lagging strand elongation	IBA	GO_REF
base-excision repair	ISO	GO_REF
double-strand break repair	ISO	GO_REF
double-strand break repair	IBA	GO_REF
double-strand break repair via nonhomologous end joining	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

double-strand break repair

double-strand break repair via nonhomologous end joining

double-strand break repair via alternative nonhomologous end joining

mitochondrial DNA repair

DNA recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

DNA biosynthetic process

nucleic acid biosynthetic process [inference]

DNA biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair

double-strand break repair

double-strand break repair via nonhomologous end joining

double-strand break repair via alternative nonhomologous end joining

mitochondrial DNA repair

DNA recombination

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

lagging strand elongation

mitochondrial DNA metabolic process [inference]

mitochondrial DNA repair

DNA biosynthetic process

nucleic acid biosynthetic process [inference]

DNA biosynthetic process

cell division

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

base-excision repair

double-strand break repair

double-strand break repair via nonhomologous end joining

double-strand break repair via alternative nonhomologous end joining

mitochondrial DNA repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

base-excision repair

double-strand break repair

double-strand break repair via nonhomologous end joining

double-strand break repair via alternative nonhomologous end joining

mitochondrial DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

base-excision repair

double-strand break repair

double-strand break repair via nonhomologous end joining

double-strand break repair via alternative nonhomologous end joining

mitochondrial DNA repair

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA recombination

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA recombination

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of cellular process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA recombination

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA recombination

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA recombination

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

negative regulation of DNA recombination

regulation of DNA replication [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

regulation of DNA-templated DNA replication [inference]

regulation of mitochondrial DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA recombination

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of mitochondrial DNA metabolic process [inference]

regulation of mitochondrial DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA recombination

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

negative regulation of DNA recombination

regulation of DNA replication [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

regulation of DNA-templated DNA replication [inference]

regulation of mitochondrial DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA recombination

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

regulation of mitochondrial DNA metabolic process [inference]

regulation of mitochondrial DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA recombination

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA replication [inference]

negative regulation of DNA-templated DNA replication [inference]

negative regulation of mitochondrial DNA replication

negative regulation of DNA recombination

negative regulation of mitochondrial DNA metabolic process [inference]

negative regulation of mitochondrial DNA replication

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
condensed nuclear chromosome	IDA	PMID
synaptonemal complex	IDA	PMID
nucleus	ISO	GO_REF
nucleus	IEA	GO_REF
nucleoplasm	ISO	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

DNA ligase III-XRCC1 complex

catalytic complex [inference]

DNA ligase III-XRCC1 complex

cellular anatomical structure [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

chromosome [inference]

nuclear chromosome [inference]

condensed nuclear chromosome

condensed chromosome [inference]

condensed nuclear chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular membraneless organelle [inference]

chromosome [inference]

nuclear chromosome [inference]

condensed nuclear chromosome

condensed chromosome [inference]

condensed nuclear chromosome

synaptonemal structure [inference]

synaptonemal complex

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
DNA binding	IEA	GO_REF
DNA ligase activity	ISO	GO_REF GO_REF
DNA ligase activity	IEA	GO_REF
DNA ligase (ATP) activity	ISO	GO_REF
DNA ligase (ATP) activity	IBA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming phosphoric ester bonds [inference]

DNA ligase activity

DNA ligase (ATP) activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA ligase activity

DNA ligase (ATP) activity

binding [inference]

nucleic acid binding [inference]

DNA binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MTLAFKILFPRNLCALGRKELCLFPEQNRWAAISQFSQWSETNLLGGCCLLQRRKPVLALQRGHLRPRATHLTFWPGSHVGLCTGPCAMAEQRFCVDYAKRGTAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARATTKKIEDLTELEGWEELEDNEKEQISQHIADLSSKAAATPKKKAAVQAKLTTTGQVTSPVKGASFITSTNPRKFSGFSAAKPNNSEQAPSSPAPGTSLSASKCDPKHKDCLLREFRKLCAMVAENPSYNTKTQIIHDFLQKGSTGGFSDGFHGDVYLTVKLLLPGVIKSVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRIFFEQSKSFPPAAKSLLTIQEVDAFLLHLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQDVVERVLHNEQEVEKDPGRRRALRVQASLMTPVQPMLAEACKSIEYAMKKCPNGMFSEIKYDGERVQVHKKGDHFSYFSRSLKPVLPHKVAHFKDYIPKAFPGGQSMILDSEVLLIDNNTGKPLPFGTLGVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIRNRIMFSEMKQVTKASDLADMINRVIREGLEGLVLKDVKGTYEPGKRHWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKGGMMSIFLMGCYDPDSQKWCTVTKCAGGHDDATLARLQKELVMVKISKDPSKIPSWLKINKIYYPDFIVPDPKKAAVWEITGAEFSRSEAHTADGISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSKDKADFAVVAGDEASPTTGGSSGENEGTAGSAGPCKGPPSKSSASAKTTEQKLNSPSSRGGIKPIPKHSPMKPGEKLAVKSSPVKVGMKRKATDETPCLKKVLLDVFTGVRLYLPPSTPDFKRLKRYFVAFDGDLVQEFDMGSATHVLGNREKNTDAQLVSSEWIWACIRKRRLIAPC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
797		36852467	G49108TO	The O-GlcNAc Database
806		36852467	G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	Mus musculus
Gap-filling DNA repair synthesis and ligation in TC-NER	Mus musculus
HDR through MMEJ (alt-NHEJ)	Mus musculus
Resolution of AP sites via the single-nucleotide replacement pathway	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements