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DNA topoisomerase 2-alpha

Summary

UniProt ID

Q01320

Gene Symbol

Top2a
Top-2
Top2

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q01320
PubChem: Q01320
The O-GlcNAc Database: Q01320
RaftProt: Q01320

Annotation

Keyword

ATP-binding
Acetylation
Biological rhythms
Cytoplasm
DNA-binding
Isopeptide bond
Magnesium
Metal-binding
Nucleus
Phosphoprotein
Reference proteome
Topoisomerase
Ubl conjugation

Gene Ontology (GO)

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GO Term
female meiosis chromosome separation
positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
DNA damage response
regulation of circadian rhythm
positive regulation of transcription by RNA polymerase II
resolution of meiotic recombination intermediates
DNA ligation
DNA topological change
sister chromatid segregation
hematopoietic progenitor cell differentiation

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GO Term
chromosome, centromeric region
condensed chromosome
nucleoplasm
centriole
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
nuclear chromosome
male germ cell nucleus
nucleus
nucleolus
cytoplasm

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GO Term
DNA binding
chromatin binding
protein homodimerization activity
ubiquitin binding
protein heterodimerization activity
DNA binding, bending
sequence-specific DNA binding
magnesium ion binding
DNA topoisomerase activity
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

Annotation information from UniProt.

Sequence

MELSPLQPVNENMLMNKKKNEDGKKRLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNVISIWNNGKGIPVVEHKVEKIYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGDMELKPFSGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNSLPVKGFRSYVDLYLKDKVDETGNSLKVIHEQVNPRWEVCLTMSERGFQQISFVNSIATSKGGRHVDYVADQIVSKLVDVVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQAKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQIQLNKKCSAVKHTKIKGIPKLDDANDAGSRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEIAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQVDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQSTSYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDHTLRFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREVVNNIRRLLDGEEPLPMLPSYKNFKGTIEELASNQYVINGEVAILDSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPSLITDYREYHTDTTVKFVIKMTEEKLAEAERVGLHKVFKLQSSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESSKLNNQARFILEKIDGKIVIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDTETSTSDSAAEAGPTFNYLLDMPLWYLTKEKKDELCKQRNEKEQELNTLKQKSPSDLWKEDLAVFIEELEVVEAKEKQDEQVGLPGKAGKAKGKKAQMCADVLPSPRGKRVIPQVTVEMKAEAEKKIRKKIKSENVEGTPAEDGAEPGSLRQRIEKKQKKEPGAKKQTTLPFKPVKKGRKKNPWSDSESDVSSNESNVDVPPRQKEQRSAAAKAKFTVDLDSDEDFSGLDEKDEDEDFLPLDATPPKAKIPPKNTKKALKTQGSSMSVVDLESDVKDSVPASPGVPAADFPAETEQSKPSKKTVGVKKTATKSQSSVSTAGTKKRAAPKGTKSDSALSARVSEKPAPAKAKNSRKRKPSSSDSSDSDFERAISKGATSKKAKGEEQDFPVDLEDTIAPRAKSDRARKPIKYLEESDDDDDLF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites