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Interferon-induced, double-stranded RNA-activated protein kinase

Summary

UniProt ID

Q03963

Gene Symbol

Eif2ak2
Pkr
Prkr
Tik

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q03963
PubChem: Q03963
The O-GlcNAc Database: Q03963

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Antiviral defense
Cytoplasm
Innate immunity
Isopeptide bond
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Repeat
Serine/threonine-protein kinase
Transcription regulation
Tyrosine-protein kinase
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 25 in total

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GO Term
positive regulation of cytokine production
translation
response to toxic substance
negative regulation of translation
negative regulation of osteoblast proliferation
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of NF-kappaB transcription factor activity
response to virus
endoplasmic reticulum unfolded protein response

Displaying **all 4** entries
GO Term
perinuclear region of cytoplasm
cytosol
nucleus
cytoplasm

Displaying **all 7** entries
GO Term
double-stranded RNA binding
eukaryotic translation initiation factor 2alpha kinase activity
non-membrane spanning protein tyrosine kinase activity
ATP binding
protein serine kinase activity
protein kinase activity
identical protein binding

Annotation information from UniProt.

Sequence

MASDTPGFYMDKLNKYRQMHGVAITYKELSTSGPPHDRRFTFQVLIDEKEFPEAKGRSKQEARNAAAKLAVDILDNENKVDCHTSASEQGLFVGNYIGLVNSFAQKKKLSVNYEQCEPNSELPQRFICKCKIGQTMYGTGSGVTKQEAKQLAAKEAYQKLLKSPPKTAGTSSSVVTSTFSGFSSSSSMTSNGVSQSAPGSFSSENVFTNGLGENKRKSGVKVSPDDVQRNKYTLDARFNSDFEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRVKYNTEKAEHEVQALAELNHVNIVQYHSCWEGVDYDPEHSMSDTSRYKTRCLFIQMEFCDKGTLEQWMRNRNQSKVDKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDERHIKIGDFGLATALENDGKSRTRRTGTLQYMSPEQLFLKHYGKEVDIFALGLILAELLHTCFTESEKIKFFESLRKGDFSNDIFDNKEKSLLKKLLSEKPKDRPETSEILKTLAEWRNISEKKKRNTC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites