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DNA topoisomerase 1

Summary

UniProt ID

Q04750

Gene Symbol

Top-1
Top1

Gene ID

21969

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q04750
PubChem: Q04750
The O-GlcNAc Database: Q04750
O-GlcNAcAtlas: Q04750
Re-Glyco: Q04750

Annotation

Keyword

Acetylation
Biological rhythms
DNA-binding
Direct protein sequencing
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Topoisomerase
Ubl conjugation

Gene Ontology (GO)

Displaying **all 9** entries
GO Term
nuclear chromosome
nucleus
cytoplasm
male germ cell nucleus
protein-DNA complex
nucleoplasm
P-body
perikaryon
fibrillar center

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying **all 6** entries
GO Term
embryonic cleavage
DNA replication
response to xenobiotic stimulus
circadian regulation of gene expression
chromatin remodeling
DNA topological change

Displaying **all 8** entries
GO Term
chromatin binding
supercoiled DNA binding
RNA polymerase II cis-regulatory region sequence-specific DNA binding
protein serine/threonine kinase activity
ATP binding
protein domain specific binding
single-stranded DNA binding
DNA topoisomerase type I (single strand cut, ATP-independent) activity

Annotation information from UniProt.

Sequence

MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKDKDKDREKSKHSNSEHKDSEKKHKEKEKTKHKDGSSEKHKDKHKDRDKERRKEEKIRAAGDAKIKKEKENGFSSPPRIKDEPEDDGYFAPPKEDIKPLKRLRDEDDADYKPKKIKTEDIKKEKKRKSEEEEDGKLKKPKNKDKDKKVAEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPESVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNDEKNTITNLSKCDFTQMSQYFKAQSEARKQMSKEEKLKIKEENEKLLKEYGFCVMDNHRERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFPGKDSIRYYNKVPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENVPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQSKIDAKKDQLADARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMTDEDYEF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites