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Prostaglandin G/H synthase 2

Summary

UniProt ID

Q05769

Gene Symbol

Ptgs2
Cox-2
Cox2
Pghs-b
Tis10

Organism

Mus musculus (house mouse)

External Links

GlyConnect

GlyGen

Q05769

PubChem

Q05769

SwissLipids

SLP:000001129

Annotation

Keyword

3D-structure
Acetylation
Dioxygenase
Direct protein sequencing
Disulfide bond
Glycoprotein
Heme
Membrane
Microsome
Nucleus
Peroxidase
Prostaglandin biosynthesis
Reference proteome
S-nitrosylation
Signal

Gene Ontology (GO)

Displaying entries **1 - 10** of 63 in total

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GO Term
positive regulation of nitric oxide biosynthetic process
negative regulation of cell cycle
negative regulation of smooth muscle contraction
positive regulation of smooth muscle contraction
positive regulation of smooth muscle cell proliferation
brown fat cell differentiation
cellular response to mechanical stimulus
cellular response to lead ion
cellular response to ATP
cellular response to non-ionic osmotic stress

Displaying **all 7** entries
GO Term
nuclear outer membrane
cytoplasm
protein-containing complex
neuron projection
caveola
endoplasmic reticulum membrane
nuclear inner membrane

Displaying **all 7** entries
GO Term
enzyme binding
metal ion binding
heme binding
protein homodimerization activity
peroxidase activity
prostaglandin-endoperoxide synthase activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

Site Annotations

Displaying 1 entry
Position	Description
592	Not glycosylated

Annotation information from UniProt.

Sequence

MLFRAVLLCAALGLSQAANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYLIDSPPTYNVHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKYQVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCDILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRVAGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKALYSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEVGFKIINTASIQSLICNNVKGCPFTSFNVQDPQPTKTATINASASHSRLDDINPTVLIKRRSTEL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
53	N-linked (GlcNAc...) asparagine	10811226 12925531 20463020 20810665 21467029 21489986 8349699 8967954	G48712ZJ G70101JE G80920RR G26335RK G64527OM G05724UK G43947VZ	UniProt GlyGen GlyConnect
130	N-linked (GlcNAc...) asparagine	10811226 12925531 20463020 20810665 21467029 21489986 8349699 8967954	G62768NK G48712ZJ G70101JE G26335RK G64527OM G05724UK G43947VZ G21001NA G39188ZX	UniProt GlyGen GlyConnect
396	N-linked (GlcNAc...) asparagine	10811226 12925531 20463020 20810665 21467029 21489986 8349699 8967954	G05724UK G43947VZ G21001NA G39188ZX G06110VR G45841FE G64581RP	UniProt GlyGen GlyConnect
580	N-linked (GlcNAc...) asparagine	20463020 8349699	G62765YT G05724UK G43947VZ G64581RP	UniProt GlyGen GlyConnect
			G62768NK G64581RP	GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
Biosynthesis of DHA-derived SPMs	Mus musculus
Biosynthesis of DPAn-3 SPMs	Mus musculus
Biosynthesis of EPA-derived SPMs	Mus musculus
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	Mus musculus
Nicotinamide salvaging	Mus musculus
Synthesis of 15-eicosatetraenoic acid derivatives	Mus musculus
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements