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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Hyaluronidase-1
Summary
- UniProt ID
- Q12794
- Gene Symbol
-
- HYAL1
- LUCA1
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- Q12794
- PubChem
- Q12794
- The Human Metabolome Database
- HMDBP09372
- The O-GlcNAc Database
- Q12794
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Direct protein sequencing
- Disease variant
- Disulfide bond
- EGF-like domain
- Glycoprotein
- Glycosidase
- Lysosome
- Mucopolysaccharidosis
- Reference proteome
- Secreted
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular space |
| cytoplasm |
| lysosome |
| cytoplasmic vesicle |
| extracellular exosome |
| hyaluranon cable |
| lysosomal lumen |
| GO Term |
|---|
| hyaluronan synthase activity |
| chondroitin hydrolase activity |
| hyalurononglucosaminidase activity |
Sequence
MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVANPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAPDFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSRALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPLDELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRCYPGWQAPWCERKSMW
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 99 | N-linked (GlcNAc...) asparagine |
|
||
| 216 | N-linked (GlcNAc...) asparagine | |||
| 350 | N-linked (GlcNAc...) asparagine |
|
||
|
|
G00912UN
G92275SC
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| CS/DS degradation | Homo sapiens |
| Hyaluronan uptake and degradation | Homo sapiens |
| MPS IX - Natowicz syndrome | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050809 | mucopolysaccharidosis IX | |
| DOID:0050865 | tongue squamous cell carcinoma | |
| DOID:0080199 | colorectal carcinoma | |
| DOID:10283 | prostate cancer | |
| DOID:10286 | prostate carcinoma | |
| DOID:11054 | urinary bladder cancer | |
| DOID:11934 | head and neck cancer | |
| DOID:12798 | mucopolysaccharidosis | |
| DOID:12799 | mucopolysaccharidosis II | |
| DOID:12800 | mucopolysaccharidosis VI |
