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Oxysterols receptor LXR-alpha

Summary

UniProt ID

Q13133

Gene Symbol

LXRA
NR1H3

Gene ID

10062

Organism

Homo sapiens (human)

External Links

GlyGen

Q13133

PubChem

Q13133

SwissLipids

SLP:000000836

The O-GlcNAc Database

Q13133

O-GlcNAcAtlas

Q13133

Re-Glyco

Q13133

Annotation

Keyword

3D-structure
Activator
Alternative splicing
Cytoplasm
DNA-binding
Nucleus
Receptor
Reference proteome
Transcription regulation
Ubl conjugation
Zinc-finger

Gene Ontology (GO)

Displaying **all 7** entries
GO Term
nucleus
chromatin
RNA polymerase II transcription regulator complex
cytoplasm
receptor complex
nucleoplasm
cytosol

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 36 in total

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GO Term
cell differentiation
negative regulation of lipid transport
positive regulation of transporter activity
regulation of circadian rhythm
negative regulation of proteolysis
positive regulation of lipid biosynthetic process
negative regulation of inflammatory response
positive regulation of protein metabolic process
positive regulation of DNA-templated transcription
positive regulation of transcription by RNA polymerase II

Displaying **all 10** entries
GO Term
zinc ion binding
sterol response element binding
RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
DNA-binding transcription activator activity, RNA polymerase II-specific
DNA binding
chromatin DNA binding
transcription cis-regulatory region binding
nuclear receptor activity
cholesterol binding

Annotation information from UniProt.

Sequence

MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
49			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 8** entries
Pathway Name	Organism
LXRs regulate gene expression linked to cholesterol transport and efflux	Homo sapiens
LXRs regulate gene expression linked to gluconeogenesis	Homo sapiens
LXRs regulate gene expression linked to lipogenesis	Homo sapiens
LXRs regulate gene expression linked to triglyceride lipolysis in adipose	Homo sapiens
LXRs regulate gene expression to control bile acid homeostasis	Homo sapiens
LXRs regulate gene expression to limit cholesterol uptake	Homo sapiens
PPARA activates gene expression	Homo sapiens
VLDLR internalisation and degradation	Homo sapiens

Disease

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:3526	cerebral infarction	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:6713	cerebrovascular disease	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements