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S-phase kinase-associated protein 2

Summary

UniProt ID

Q13309

Gene Symbol

SKP2
FBXL1

Organism

Homo sapiens (human)

External Links

GlyGen: Q13309
PubChem: Q13309
The O-GlcNAc Database: Q13309

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Antiviral defense
Cytoplasm
Direct protein sequencing
Host-virus interaction
Innate immunity
Leucine-rich repeat
Nucleus
Phosphoprotein
Reference proteome
Repeat
Ubl conjugation
Ubl conjugation pathway

Gene Ontology (GO)

Displaying entries **1 - 10** of 13 in total

1

2

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GO Term
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of double-strand break repair via homologous recombination
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
positive regulation of intracellular estrogen receptor signaling pathway
protein K63-linked ubiquitination
protein K48-linked ubiquitination
regulation of apoptotic process
innate immune response
defense response to virus
regulation of cell cycle

Displaying **all 5** entries
GO Term
nucleoplasm
cytosol
nucleus
nucleolus
SCF ubiquitin ligase complex

Displaying **all 2** entries
GO Term
identical protein binding
ubiquitin ligase-substrate adaptor activity

Annotation information from UniProt.

Sequence

MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLGHPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQKPSCL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
34			G49108TO	The O-GlcNAc Database
210			G83460ZZ	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 10** entries
Pathway Name	Organism
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	Homo sapiens
Aberrant regulation of mitotic exit in cancer due to RB1 defects	Homo sapiens
Antigen processing: Ubiquitination & Proteasome degradation	Homo sapiens
Cyclin D associated events in G1	Homo sapiens
Neddylation	Homo sapiens
Orc1 removal from chromatin	Homo sapiens
Regulation of BACH1 activity	Homo sapiens
Regulation of RUNX2 expression and activity	Homo sapiens
SCF(Skp2)-mediated degradation of p27/p21	Homo sapiens
Ub-specific processing proteases	Homo sapiens