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Sodium channel protein type 5 subunit alpha

Summary

UniProt ID

Q14524

Gene Symbol

SCN5A

Organism

Homo sapiens (human)

External Links

GlyGen: Q14524
PubChem: Q14524
The Human Metabolome Database: HMDBP09086
The O-GlcNAc Database: Q14524
O-GlcNAcAtlas: Q14524

Annotation

Keyword

3D-structure
Alternative splicing
Atrial fibrillation
Brugada syndrome
Calmodulin-binding
Cardiomyopathy
Cell junction
Cell membrane
Cytoplasm
Disease variant
Disulfide bond
Glycoprotein
Long QT syndrome
Methylation
Phosphoprotein
Reference proteome
Repeat
Sodium channel
Transmembrane helix
Ubl conjugation
Voltage-gated channel

Gene Ontology (GO)

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GO Term
sodium ion transport
positive regulation of epithelial cell proliferation
membrane depolarization
positive regulation of sodium ion transport
neuronal action potential
telencephalon development
cerebellum development
sodium ion transmembrane transport
odontogenesis of dentin-containing tooth
positive regulation of action potential

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GO Term
voltage-gated sodium channel complex
nucleoplasm
endoplasmic reticulum
cell surface
intercalated disc
perinuclear region of cytoplasm
nucleolus
plasma membrane
membrane
axon

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GO Term
transmembrane transporter binding
fibroblast growth factor binding
voltage-gated sodium channel activity
calmodulin binding
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
voltage-gated sodium channel activity involved in AV node cell action potential
voltage-gated sodium channel activity involved in bundle of His cell action potential
voltage-gated sodium channel activity involved in Purkinje myocyte action potential
voltage-gated sodium channel activity involved in SA node cell action potential
scaffold protein binding

Annotation information from UniProt.

Sequence

MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVNSHERRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSEDLADFPPSPDRDRESIV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	GlyTouCan ID	Source
214	N-linked (GlcNAc...) asparagine		UniProt GlyGen
283	N-linked (GlcNAc...) asparagine		UniProt GlyGen
288	N-linked (GlcNAc...) asparagine		UniProt GlyGen
291	N-linked (GlcNAc...) asparagine		UniProt GlyGen
318	N-linked (GlcNAc...) asparagine	G14943SF	UniProt GlyGen
328	N-linked (GlcNAc...) asparagine	G26436YP	UniProt GlyGen
740	N-linked (GlcNAc...) asparagine		UniProt GlyGen
803	N-linked (GlcNAc...) asparagine		UniProt GlyGen
864	N-linked (GlcNAc...) asparagine		UniProt GlyGen
1026		G49108TO	GlyGen The O-GlcNAc Database