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Cyclin-dependent kinase 12

Summary

UniProt ID

Q14AX6

Gene Symbol

Cdk12
Crk7
Crkrs
Kiaa0904

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q14AX6
PubChem: Q14AX6
The O-GlcNAc Database: Q14AX6
O-GlcNAcAtlas: Q14AX6

Annotation

Keyword

ATP-binding
Alternative splicing
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Ubl conjugation
mRNA splicing

Gene Ontology (GO)

Displaying **all 9** entries
GO Term
negative regulation of stem cell differentiation
protein autophosphorylation
regulation of MAP kinase activity
transcription by RNA polymerase II
RNA splicing
regulation of RNA splicing
positive regulation of transcription by RNA polymerase II
mRNA processing
positive regulation of transcription elongation by RNA polymerase II

Displaying **all 5** entries
GO Term
nuclear speck
cyclin K-CDK12 complex
cyclin/CDK positive transcription elongation factor complex
nuclear cyclin-dependent protein kinase holoenzyme complex
nucleus

Displaying **all 7** entries
GO Term
protein kinase binding
cyclin binding
cyclin-dependent protein serine/threonine kinase activity
ATP binding
RNA polymerase II CTD heptapeptide repeat kinase activity
protein serine kinase activity
protein kinase activity

Annotation information from UniProt.

Sequence

MPNSERHGGKKDGSGGASGTSQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDVGLVTPEAASLGTIIKPLVEYDDISSDSDTFSDDTAFKSDRRENEERRGTDRSDRLHRHRHHQHRRSRDLLKTKQTEKEKNQEVSKSGSMKDRVSGSSKRSVEGSDDYGKAQLSKSGSKESRSSKMHKEKTRKERELKSGYKDRSKSHRKRETPKSYKTVASPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPPRSHTSSNYDSYKKSPGSTSRRQSISPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSGSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKSSPIILPKKEKLEVKESGLESKKLPRSIKSEKSTPDTELVTVAHSNPEVKHCLDTGKVRLDENLQKHPAKDLKAQGTKDVKPVAPKEVIVTSKETETSEKETLPPLPTITSPPPLPATTPPPQTPPLPPLPPLPAIPLQPPLPPPQPPFSQVPVSSTSILPSSPHPRTSTLSSQTNSQPPVQVSMKTQVSITAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKETLPSKPAKKEKEQRTRHLLTDLPLPPELPGGDPSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGIVIEDPPPSKASRKETTSGTTAEPVKNNSPAPPQPAPVKAEPGPGDAVGLGDITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEASSQQQDSESIAPEESLKEVPSVPVVLPPAEQTTPEASNTPADMQNVLAVLLSQLMKTQEPAGNLEENTNDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRSHPNRTYGNTDGPETGFSSADTDERSSGPALTESLVQTPVKNRTFSGSVSHLGESNSYQGTGSVQFPGDQDLRFTRVPLALHSVVGQPFLKSEGNSNSVVHAETKLQNYGELGPGTTGANSSGTTLQWGGPAQSYGKPYRGAARVLPRGGRGRGVPY

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 6** entries
Position	GlyTouCan ID	Source
588	G49108TO	GlyGen The O-GlcNAc Database
589	G49108TO	GlyGen The O-GlcNAc Database
590	G49108TO	GlyGen
592	G49108TO	GlyGen
593	G49108TO	GlyGen
1359	G49108TO	GlyGen The O-GlcNAc Database