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Receptor tyrosine-protein kinase erbB-4

Summary

UniProt ID

Q15303

Gene Symbol

ERBB4
HER4

Gene ID

2066

Organism

Homo sapiens (human)

External Links

GlyGen: Q15303
PubChem: Q15303
The Human Metabolome Database: HMDBP01376
Re-Glyco: Q15303

Annotation

Keyword

3D-structure
ATP-binding
Activator
Alternative splicing
Amyotrophic lateral sclerosis
Apoptosis
Cell membrane
Developmental protein
Disease variant
Disulfide bond
Glycoprotein
Lactation
Mitochondrion
Nucleus
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transcription regulation
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Gene Ontology (GO)

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GO Term
extracellular region
nucleus
mitochondrion
mitochondrial matrix
plasma membrane
neuromuscular junction
receptor complex
postsynaptic membrane
nucleoplasm
cytosol

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

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GO Term
transmembrane receptor protein tyrosine kinase signaling pathway
heart development
positive regulation of tyrosine phosphorylation of STAT protein
negative regulation of neuron migration
signal transduction
nervous system development
lactation
positive regulation of cell population proliferation
negative regulation of cell population proliferation
cell migration

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GO Term
ATP binding
placental growth factor receptor activity
protein homodimerization activity
transcription cis-regulatory region binding
epidermal growth factor receptor binding
GABA receptor binding
macrophage colony-stimulating factor receptor activity
platelet-derived growth factor alpha-receptor activity
stem cell factor receptor activity
boss receptor activity

Annotation information from UniProt.

Sequence

MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	PubMed ID	GlyTouCan ID	Source
138	N-linked (GlcNAc...) asparagine	16203964	G31852PQ G41247ZX G02815KT	UniProt GlyGen
174	N-linked (GlcNAc...) asparagine	16203964		UniProt GlyGen
181	N-linked (GlcNAc...) asparagine			UniProt GlyGen
253	N-linked (GlcNAc...) asparagine	16203964		UniProt GlyGen
358	N-linked (GlcNAc...) asparagine	16203964		UniProt GlyGen
410	N-linked (GlcNAc...) asparagine	16203964		UniProt GlyGen
473	N-linked (GlcNAc...) asparagine	16203964		UniProt GlyGen
495	N-linked (GlcNAc...) asparagine	16203964		UniProt GlyGen
548	N-linked (GlcNAc...) asparagine			UniProt GlyGen
576	N-linked (GlcNAc...) asparagine	16203964		UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Disease

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0060210	amyotrophic lateral sclerosis type 19	Alliance of Genome Resources
DOID:3748	esophagus squamous cell carcinoma	Alliance of Genome Resources
DOID:3910	lung adenocarcinoma	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:9256	colorectal cancer	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements