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Tumor necrosis factor receptor type 1-associated DEATH domain protein

Summary

UniProt ID

Q3U0V2

Gene Symbol

Tradd

Gene ID

71609

Organism

Mus musculus (house mouse)

External Links

PubChem: Q3U0V2
Re-Glyco: Q3U0V2

Annotation

Keyword

Apoptosis
Cytoskeleton
Glycoprotein
Nucleus
Reference proteome

Gene Ontology (GO)

Displaying **all 5** entries
GO Term
nucleus
cytoplasm
cytoskeleton
plasma membrane
tumor necrosis factor receptor superfamily complex

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 11 in total

1

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GO Term
positive regulation of execution phase of apoptosis
positive regulation of cell migration
positive regulation of inflammatory response
extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of interferon-beta production
tumor necrosis factor-mediated signaling pathway
extrinsic apoptotic signaling pathway
canonical NF-kappaB signal transduction
positive regulation of canonical NF-kappaB signal transduction
TRAIL-activated apoptotic signaling pathway

Displaying **all 6** entries
GO Term
transmembrane receptor protein tyrosine kinase adaptor activity
tumor necrosis factor receptor binding
signaling adaptor activity
identical protein binding
protein-containing complex binding
death domain binding

Annotation information from UniProt.

Sequence

MAAGQNGHEEWVGSAYLFLESAVDKVILSEAYTDPKKKVAIYKALQTALSESGDSSDVLQILKIHCSDPQLIVQLRFCGRVLCGRFLQAYREGALRTALQRCMAPALAQEALRLQLELRAGAEQLDSWLTDEERCLNYILAQKPDRLRDEELAELEDELCKLTCDCTGQGGAIQVASAGSKFPVSSPTEEKPLPAACQTFLFHGQLVVNRPLTLQDQQTFARSVGLKWRRVGRSLQRNCRALRDPALDSLAYEYERDGLYEQAFQLLRRFMQAEGRRATLQRLVEALEENELTSLAEDLLGQAEPDGGLA

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
243	(Microbial infection) N-beta-linked (GlcNAc) arginine	30902834		UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 8** entries
Pathway Name	Organism
CASP8 activity is inhibited	Mus musculus
Dimerization of procaspase-8	Mus musculus
Regulation by c-FLIP	Mus musculus
Regulation of TNFR1 signaling	Mus musculus
Regulation of necroptotic cell death	Mus musculus
TNF signaling	Mus musculus
TNFR1-induced NF-kappa-B signaling pathway	Mus musculus
TNFR1-induced proapoptotic signaling	Mus musculus