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Fibroblast growth factor receptor 4

Summary

UniProt ID

Q498D6

Gene Symbol

Fgfr4

Gene ID

25114

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: Q498D6
Re-Glyco: Q498D6

Annotation

Keyword

ATP-binding
Cell membrane
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Immunoglobulin domain
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation

Gene Ontology (GO)

Displaying **all 7** entries
GO Term
plasma membrane
cell-cell junction
receptor complex
endosome
endoplasmic reticulum
Golgi apparatus
transport vesicle

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 26 in total

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GO Term
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of extracellular matrix disassembly
regulation of phosphate transport
cholesterol homeostasis
protein autophosphorylation
regulation of bile acid biosynthetic process
positive regulation of parathyroid hormone secretion
positive regulation of cell population proliferation
positive regulation of gene expression
negative regulation of gene expression

Displaying entries **1 - 10** of 21 in total

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GO Term
fibroblast growth factor binding
placental growth factor receptor activity
GPI-linked ephrin receptor activity
transmembrane-ephrin receptor activity
hepatocyte growth factor receptor activity
insulin receptor activity
insulin-like growth factor receptor activity
platelet-derived growth factor beta-receptor activity
histone H2AXY142 kinase activity
heparin binding

Annotation information from UniProt.

Sequence

MWLLLALLSIFQETPAFSLEASEEMEQEPCPAPISEQQEQVLTVALGQPVRLCCGRTERGRHWYKEGSRLASAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMTVVHNLTLIMDDSLPSINNEDPKTLSSSSSGHSYLQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPMPTIHWLKNGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVGSNVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPAEEEDLAWTTATSEARYTDIILYVSGSLALVLLLLLAGVYHRQAIHGHHSRQPVTVQKLSRFPLARQFSLESRSSGKSSLSLVRGVRLSSSGPPLLTGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEALGMDSSRPDQTSTVAVKMLKDNASDKDLADLISEMEMMKLIGRHKNIINLLGVCTQEGPLYVIVEYAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPNNGDASSTCSSSDSVFSHDPLPLEPSPFPFPEAQTT

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	Source
109	N-linked (GlcNAc...) asparagine	UniProt
254	N-linked (GlcNAc...) asparagine	UniProt
286	N-linked (GlcNAc...) asparagine	UniProt
307	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 11 in total

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Pathway Name	Organism
FGFR4 ligand binding and activation	Rattus norvegicus
FRS-mediated FGFR4 signaling	Rattus norvegicus
Negative regulation of FGFR4 signaling	Rattus norvegicus
PI-3K cascade:FGFR4	Rattus norvegicus
PI3K Cascade	Rattus norvegicus
PI3K/AKT Signaling	Rattus norvegicus
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Rattus norvegicus
Phospholipase C-mediated cascade; FGFR4	Rattus norvegicus
RAF/MAP kinase cascade	Rattus norvegicus
SHC-mediated cascade:FGFR4	Rattus norvegicus

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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International Collaboration

Acknowledgements