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Angiotensin-converting enzyme

Summary

UniProt ID: Q50JE5
Gene Symbol: Ace LOC101824864 ACE Dcp1
Gene ID: 101824864
Organism: Mesocricetus auratus (golden hamster)

External Links

PubChem: Q50JE5
Re-Glyco: Q50JE5

Annotation

Keyword: Alternative promoter usage Calmodulin-binding Carboxypeptidase Cell membrane Cytoplasm Disulfide bond Glycoprotein Metal-binding Metalloprotease Phosphoprotein Reference proteome Repeat Secreted Signal Transmembrane helix Zinc

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
kidney development	ISS	GO_REF
angiotensin maturation	ISS	GO_REF
positive regulation of systemic arterial blood pressure	IEA	GO_REF GO_REF
regulation of blood pressure	ISS	GO_REF
substance P catabolic process	ISS	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

catabolic process [inference]

peptide catabolic process [inference]

neuropeptide catabolic process [inference]

substance P catabolic process

hormone metabolic process

peptide hormone processing [inference]

angiotensin maturation

hormone catabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

angiotensin maturation

developmental process [inference]

anatomical structure development [inference]

animal gross anatomical part developmental process [inference]

animal organ development [inference]

kidney development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation

regulation of biological quality [inference]

regulation of blood pressure

positive regulation of blood pressure [inference]

positive regulation of systemic arterial blood pressure

regulation of hormone levels [inference]

hormone metabolic process

peptide hormone processing [inference]

angiotensin maturation

hormone catabolic process

regulation of synaptic plasticity

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GO Term	Evidence Code	Reference
extracellular region	ISS	GO_REF
extracellular region	IEA	GO_REF
obsolete extracellular space
cytoplasm	ISS	GO_REF
cytoplasm	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

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GO Term	Evidence Code	Reference
carboxypeptidase activity
metalloendopeptidase activity	ISS	GO_REF
calmodulin binding
peptidase activity	ISS	GO_REF
peptidyl-dipeptidase activity	ISS	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

metalloexopeptidase activity [inference]

metallodipeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metalloexopeptidase activity [inference]

metallodipeptidase activity

peptidyl-dipeptidase activity

dipeptidase activity [inference]

metallodipeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

metalloexopeptidase activity [inference]

metallodipeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metalloexopeptidase activity [inference]

metallodipeptidase activity

peptidyl-dipeptidase activity

dipeptidase activity [inference]

metallodipeptidase activity

binding [inference]

protein binding [inference]

calmodulin binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

chloride ion binding

cation binding [inference]

metal ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MGAASGQRGQGPPSPLLLLWLSLLLLLLPPSPAPALDPGLQPGNFSADEIGAHLFAESYNSSAEQVIFQSTVASWAYDTNMTEENARLQEEAELIWQEFAEVWGKKAKELFDAIRQNFTDSKLRRVIETIRTLGPANLPLARRQQYNSLQNNMNRIYSTSKVCLPNKTATCWSLEPELTNILASSRSYAKLLFAWESWHDVVGIPLKPLYQDFTALSNEAYKQDGFSDTGAYWRSAYDSPSFEETLEHLYHQLEPLYLNLHAYVRRALHRRYGDKYINLRGPIPAHLLGDMWAQSWDNIYDMVVPFPNKPNLDVTNTMVQKGWNVTHMFRVAEEFFTSMGLSPMPPEFWAESMLEKPTDGREVVCHASAWDFFNRKDFRIKQCTRITMEQLSTVHHEMGHVQYYLQYKDLTVPLRRGANPGFHEAIGDVLALSVSTPAHLHKIGLLDRVANDLESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGHTPPSRYNFDWWYFRTKYQGICPPVVRNETHFDAGAKFHIPSGTPYIRYFVSFILQFQFHQALCKEAGHQGPLHQCDIYQSTQAGAKLQRVLQAGYSRPWQEVLKEMVGSDTLDAQALLEYFQPVIRWLQEQNQRNGEVLGWPEYQWRPPLPDNYPEGIDLVTDETEAERFVEEYDRTARVLWNEYAEANWQYNTNITLEASKILLQKNKKVANHTLKYGTLAKKFDVSNFQNYTIKRIIKKVQNMDRAVLPPKELEEYNQILMDMETTYSIANVCYLNGTCLHLEPDLTNVMATSRKYEELLWVWKSWRDKVGRAILPLFPKYVELSNKIAHLNGYADGGDSWRSSYESKSLEQDLEQLYQELQPLYLNLHAYVRRSLHRHYGSQHINLDGPIPAHLLGNMWAQTWSNIYDLVAPFPSAPNLDATEAMIKQGWTPRRIFKEADDFFTSLGLLPVSEEFWNKSMLEKPGDGREVVCHASAWDFYNGKDFRIKQCTSVNMEDLVIAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGGYEHDINFLMKMALDKIAFIPFSYLIDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRSQDDFDPGSKFHVPANVPYIRYFVSFIIQFQFHEALCRAAGHTGPLHKCDIYQSKEAGKLLADTMKMGYSKPWPEAMKLITGQPNMSASAMMNYFKPLTEWLVTENRRHGETLGWPEYNWTPNTARSEGPFPESGRVNFLGMYLEPQQARVGQWVLLFLGVSLLVATLGLTHRLFSIRQHGHSLHRPHRGPQFGSEVELRHS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	Source
44	N-linked (GlcNAc...) asparagine	UniProt
60	N-linked (GlcNAc...) asparagine	UniProt
80	N-linked (GlcNAc...) asparagine	UniProt
117	N-linked (GlcNAc...) asparagine	UniProt
166	N-linked (GlcNAc...) asparagine	UniProt
324	N-linked (GlcNAc...) asparagine	UniProt
515	N-linked (GlcNAc...) asparagine	UniProt
683	N-linked (GlcNAc...) asparagine	UniProt
701	N-linked (GlcNAc...) asparagine	UniProt
720	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

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