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Major prion protein

Summary

UniProt ID

Q53YK7

Gene Symbol

PRNP

Organism

Homo sapiens (human)

External Links

GlycoProtDB: GPDB0012058

Annotation

Keyword

Cell membrane
Copper
Disulfide bond
GPI-anchor
Golgi apparatus
Metal-binding
Prion
Repeat
Signal
Transmembrane helix
Zinc

Gene Ontology (GO)

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GO Term
regulation of potassium ion transmembrane transport
positive regulation of protein localization to plasma membrane
cellular response to amyloid-beta
negative regulation of interleukin-2 production
negative regulation of activated T cell proliferation
response to copper ion
positive regulation of peptidyl-tyrosine phosphorylation
regulation of glutamate receptor signaling pathway
neuron projection maintenance
learning or memory

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GO Term
endoplasmic reticulum
Golgi apparatus
cytosol
cell surface
side of membrane
terminal bouton
postsynaptic density
plasma membrane
dendrite
nuclear membrane

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GO Term
molecular condensate scaffold activity
lamin binding
type 5 metabotropic glutamate receptor binding
protease binding
glycosaminoglycan binding
aspartic-type endopeptidase inhibitor activity
identical protein binding
transmembrane transporter binding
protein-containing complex binding
protein-folding chaperone binding

Annotation information from UniProt.

Sequence

MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites