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Receptor-interacting serine/threonine-protein kinase 1

Summary

UniProt ID

Q60855

Gene Symbol

Ripk1
Rinp
Rip

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q60855
PubChem: Q60855
The O-GlcNAc Database: Q60855

Annotation

Keyword

3D-structure
ATP-binding
Apoptosis
Cell membrane
Cytoplasm
Host-virus interaction
Inflammatory response
Isopeptide bond
Necrosis
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Ubl conjugation

Gene Ontology (GO)

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GO Term
positive regulation of phosphorylation
positive regulation of inflammatory response
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of neuron apoptotic process
positive regulation of macrophage differentiation
T cell apoptotic process
positive regulation of execution phase of apoptosis

Displaying **all 5** entries
GO Term
receptor complex
death-inducing signaling complex
mitochondrion
ripoptosome
protein-containing complex

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GO Term
protein kinase activity
protein serine/threonine kinase activity
protein-containing complex binding
death domain binding
ubiquitin protein ligase binding
protein homodimerization activity
JUN kinase kinase kinase activity
death receptor binding
ATP binding
signaling adaptor activity

Annotation information from UniProt.

Sequence

MQPDMSLDNIKMASSDLLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVLLEEGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGRIIVEAIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYENVICTEQFVICIKSGNRPNVEEILEYCPREIISLMERCWQAIPEDRPTFLGIEEEFRPFYLSHFEEYVEEDVASLKKEYPDQSPVLQRMFSLQHDCVPLPPSRSNSEQPGSLHSSQGLQMGPVEESWFSSSPEYPQDENDRSVQAKLQEEASYHAFGIFAEKQTKPQPRQNEAYNREEERKRRVSHDPFAQQRARENIKSAGARGHSDPSTTSRGIAVQQLSWPATQTVWNNGLYNQHGFGTTGTGVWYPPNLSQMYSTYKTPVPETNIPGSTPTMPYFSGPVADDLIKYTIFNSSGIQIGNHNYMDVGLNSQPPNNTCKEESTSRHQAIFDNTTSLTDEHLNPIRENLGRQWKNCARKLGFTESQIDEIDHDYERDGLKEKVYQMLQKWLMREGTKGATVGKLAQALHQCCRIDLLNHLIRASQS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
CASP8 activity is inhibited	Mus musculus
Dimerization of procaspase-8	Mus musculus
IKK complex recruitment mediated by RIP1	Mus musculus
Ligand-dependent caspase activation	Mus musculus
Ovarian tumor domain proteases	Mus musculus
RIPK1-mediated regulated necrosis	Mus musculus
Regulation by c-FLIP	Mus musculus
Regulation of TNFR1 signaling	Mus musculus
Regulation of necroptotic cell death	Mus musculus
TNF signaling	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

External Links

Annotation

International Collaboration

Acknowledgements