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Frizzled-4
Summary
- UniProt ID
- Q61088
- Gene Symbol
-
- Fzd4
- Gene ID
- 14366
- Organism
- Mus musculus (house mouse)
External Links
- GlycoProtDB
- GPDB0005450
- PubChem
- Q61088
- Re-Glyco
- Q61088
Annotation
- Keyword
-
- Cell membrane
- Developmental protein
- Disulfide bond
- G-protein coupled receptor
- Glycoprotein
- Reference proteome
- Signal
- Transmembrane helix
- Ubl conjugation
- Wnt signaling pathway
- Gene Ontology (GO)
| GO Term |
|---|
| dendrite |
| synapse |
| cell surface |
| plasma membrane |
| cell-cell junction |
| glutamatergic synapse |
| GO Term |
|---|
| protein heterodimerization activity |
| PDZ domain binding |
Sequence
MAWPGTGPSSRGAPGGVGLRLGLLLQFLLLLRPTLGFGDEEERRCDPIRIAMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLREFGFAWPDTLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGSNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTTFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGNETVV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 59 | N-linked (GlcNAc...) asparagine |
|
||
| 144 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Asymmetric localization of PCP proteins | Mus musculus |
| Ca2+ pathway | Mus musculus |
| Cargo recognition for clathrin-mediated endocytosis | Mus musculus |
| Clathrin-mediated endocytosis | Mus musculus |
| Regulation of FZD by ubiquitination | Mus musculus |
| WNT5A-dependent internalization of FZD4 | Mus musculus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050535 | exudative vitreoretinopathy | |
| DOID:0060844 | Norrie disease |
