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Macrophage metalloelastase

Summary

UniProt ID

Q63341

Gene Symbol

Mmel
Mmp12

Gene ID

117033

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: Q63341
Re-Glyco: Q63341

Annotation

Keyword

Calcium
Disulfide bond
Extracellular matrix
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Repeat
Signal
Zinc
Zymogen

Gene Ontology (GO)

Displaying **all 4** entries
GO Term
extracellular space
nucleus
cytoplasm
extracellular matrix

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 23 in total

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GO Term
response to hypoxia
proteolysis
positive regulation of gene expression
extracellular matrix organization
positive regulation of epithelial cell proliferation
positive regulation of transcription by RNA polymerase II
regulation of defense response to virus by host
elastin catabolic process
negative regulation of endothelial cell-matrix adhesion via fibronectin
negative regulation of transcription by RNA polymerase II

Displaying **all 6** entries
GO Term
calcium ion binding
zinc ion binding
metalloendopeptidase activity
collagen binding
sequence-specific DNA binding
core promoter sequence-specific DNA binding

Annotation information from UniProt.

Sequence

MKFLLVLVLLVSLQVSACGAAPMNESEFAEWYLSRFFDYQGDRIPMTKTKTNRNLLEEKLQEMQQFFGLEVTGQLDTSTLKIMHTSRCGVPDVQHLRAVPQRSRWMKRYLTYRIYNYTPDMKRADVDYIFQKAFQVWSDVTPLRFRKIHKGEADITILFAFGDHGDFYDFDGKGGTLAHAFYPGPGIQGDAHFDEAETWTKSFQGTNLFLVAVHELGHSLGLRHSNNPKSIMYPTYRYLHPNTFRLSADDIHSIQSLYGAPVKNPSLTNPGSPPSTVCHQSLSFDAVTTVGDKIFFFKDWFFWWRLPGSPATNITSISSMWPTIPSGIQAAYEIGGRNQLFLFKDEKYWLINNLVPEPHYPRSIHSLGFPASVKKIDAAVFDPLRQKVYFFVDKQYWRYDVRQELMDAAYPKLISTHFPGIRPKIDAVLYFKRHYYIFQGAYQLEYDPLLDRVTKTLSSTSWFGC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
313	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Collagen degradation	Rattus norvegicus
Degradation of the extracellular matrix	Rattus norvegicus

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:13139	crescentic glomerulonephritis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements