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Histone-lysine N-methyltransferase 2D
Summary
- UniProt ID
- Q6PDK2
- Gene Symbol
-
- Kmt2d
- Mll2
- Mll4
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- Acetylation
- Chromatin regulator
- Coiled coil
- Isopeptide bond
- Methylation
- Methyltransferase
- Nucleus
- Phosphoprotein
- Reference proteome
- Repeat
- S-adenosyl-L-methionine
- Transcription regulation
- Ubl conjugation
- Zinc-finger
- Gene Ontology (GO)
| GO Term |
|---|
| histone methyltransferase complex |
| nucleoplasm |
| GO Term |
|---|
| in utero embryonic development |
| regulation of gene expression |
| oogenesis |
| oocyte growth |
| heterochromatin formation |
| methylation |
Sequence
MDSQKPPAEDKDSDPAADGLAAPEKPGATEPDLPILCIGEVSVPGSGGSRPQKPPHDCSRGPARRCALCNCGEPGLHGQRELQRFELPSDWPGFPVVPSGGNSGPCEAVLPKEDASQIGFPEGLTPAHLGEPGGHCWAHHWCAAWSAGVWGQEGPELCGVDKAIFSGISQRCSHCARFGASVPCRSPGCSRLYHFPCATASGSFLSMKTLQLLCPEHSDGAAHLEEARCAVCEGPGQLCDLLFCTSCGHHYHGACLDTALTARKRASWQCPECKVCQSCRKPGNDSKMLVCETCDKGYHTFCLKPPMEDLPAHSWKCKTCRLCRACGAGSAELNPNSEWFENYSLCHRCHKAQGSQPVTSVAEQHPAVCSRLSPPEPGEIPIDAPDALYVACQGQPKGGHVTSMQPKELAPLQCEAKPLGRAGTQLEAQLEAPLHEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPTEESPLSPPPESSPFSPLEGCPPSPALDTPLSPPPEASPLSPPFEESPLSPPPEELPSSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEDSPLSPPPEASRLSPPPEDSPMSPPPEDSPMSPPPEVSRFLPLPVLSHLSPLPEVSRLSPPPEESPLSPPPEDSPASPPPEASRLSPPPEDSPASPPPEASRLSRPREDSPASPPPEDSLVSLPMEESPLSPLPEELRLCPQPEEPYLSPQPEEPRLCPQPEELPLSPQSEEPCLSPVLVEPGPSSQPEEPHLSPVPQEPHLSPQPEEPHLSPQPQQLHLSPHSEEPCLSPMPEEPCLSPQPEELNGPPQPAEPPEEPSQSSAPKELSLFSPSGEPPLPPMLGEPALSEPGEPPLSPLPEELPLSLSGEPVLSPQLMPPDPLPPPLSPIIPAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPLGPASPILMERLPPPCSPLLPHSLPPPTPPPSHCSPPALPLSVPSPLSPVQKAVDVSDEAELHEMETDKGPEPECPALEPRATSPLPSPLGDLSCPAPSPAPALDDFSGLGEDTAPLDGTGQMSGSLAGELKGSPVLLDPEELTPVTPMEVYGPECKQAGQGSPCEEQEEPGAPMAPMPPTLIKSDIVNEISNLSQGDASASFPGSEPLLGSPDPEGGGSLSMELGVSTDVSPARDEGSLRLCTDSLPETDDSLLCDTGTATSGGKAEGDKGRRRSSPARSRIKQGRSSSFPGRRRPRGGAAHGGRGRGRARLKSTTSSVETLVADIDSSPSKEEEEEDDDTMQNTVVLFSNTDKFVLMQDMCVVCGSFGRGAEGHLLACSQCSQCYHPYCVNSKITKVMLLKGWRCVECIVCEVCGQASDPSRLLLCDDCDISYHTYCLDPPLLTVPKGGWKCKWCVSCMQCGAASPGFHCEWQNSYTHCGPCASLVTCPVCHAPYVEEDLLIQCRHCERWMHAGCESLFTEDEVEQAADEGFDCVSCQPYVVKPVVPVAPPELVPVKVKEPEPQFFRFEGVWLTETGMAVLRNLTMSPLHKRRQRRGRLGLPGEAGLEGSEPSDALGPDDKKDGDLDTDDLLKGEGGVEQMECEIKLEGPASPDVELGKEETEESKKRKRKPYRPGIGGFMVRQRKSHTRVKRGPAAQAEVLSGDGQPDEVMPADLPAEGSVEQSLAEGDEKKKQQRRARKKSKLEDMFPAYLQAAFFGKDLLDLSRKALFAVGVGRPGFGLGASKPRADGGSDRKELMTAMHKGDDGPDVADEESHGPEGTADLPGLEDGGVKASPVPSDPEKPGTPGEGVLSSDLDRIPTEELPKMESKDLQQLFKDVLGSEREQHLGCGTPGLEGGRTSLQRPFLQGGLALGSLPSSSPMDSYPGLCQSPFLDSRERGGFFSPEPGEPDSPWTGSGGTTPSTPTTPTTEGEGDGLSYNQRSLQRWEKDEELGQLSTISPVLYANINFPNLKQDYPDWSSRCKQIMKLWRKVPAADKAPYLQKAKDNRAAHRISKVQKQAESQISKQAKMGDIARKTDRPALHLRIPSQPGALGSPPPAAAPTIFLGSPTTPAGLSTSADGFLKPPAGTVPGPDSPGELFLKLPPQVPAQVPSQDPFGLAPAYAPEPRFSAAPPTYPPYPSPTGAPAQPPMLGTTTRPGTGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVAGGKASEPLLSPPPFGESRKSLEVKKEELGASSPGYGPPNLGCVDSPSAGPHLGGLELKAPDVFKAPLTPRASQVEPQSPGLGLRAQEPPPAQALAPSPPSHPDVFRSGPYPDPYAQPPLTPRPQPPPPESCCAPPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFKAGPLAHTPLGAGGFPAALPSGPAGELHAKVPSGQPTNFARSPGTGTFVGTPSPMRFTFPQGVGEPSLKPPVPQPGLPSPHGINSHFGPGPTLGKPQSTNYAVATGNFHPSGSPLGPNSGPTGEGYGLSPLRPASVLPPPAPDGSLPYLTHGASQRVGITSPVEKREDPGATMSSSSLATPELSSAQDAGISSLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGNWGAEPSSPAFEQLSRGQTPFTGSQDRSSIVGLPASKLGGPTLGPGAFSSDDRLARPLPPATPSSMDMNSRQLVGGSQAFYQRTPYPGSLPLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLWQQQQQQQQQQQQQAAAAAAATSMRLAMSARFPSTPGPELGRQALGSPLAGIPTRLPGPAEPVPGPAGPAQFIELRHNVQKGLGPGVSPFPGQGPPQRPRFYPVSEELHRLAPEGLRGLAVPGLPSQKPSALPAPELNNSLHQTPHAKGPALASGLELVSRPPSNTELSRPPLALEAGKLPCEDPELDDDFDAHKALEDDEELAHLGLGVDVAKGDDELGTLENLETNDPHLDDLLNGDEFDLLAYTDPELDTGDKKDIFNEHLRLVESANEKAEREALLRGVEPVSLGPEERPPPAPDNSEPRLTSVLPEVKPKVEEGGRHPSPCQFTINTPKVEPAPPATSLSLGLKPGQTVMGTRDTRGGVGTGSFPSSGHTAEKGPFGATGGTPAHLLNPSSLSGPAASSLLEKFELESGALTLPSGHAAAGDELDKMESSLVASELPLLIEDLLEHEKKELQKKQQLSAQTVLPAQQQQQQQQQQQQQQQQHTLLPTPGPAQALPLPHEPGPPQQLALGIGSTRQPGLGQSMVPIQPPAHALQQRLAPSVAMVSNQGHMLSGQQAGQTGLVPQQSSQPVLAQKPMSAMPASMCMKPQQLAMQQQQLANSFFPDTDLDKFAAEDIIDPIAKAKMVALKGIKKVMAQGSIGVAPGMNRQQVSLLAQRLSGGSGSDLQNHVAPGSGQERNAGDPAQPRPNPPTFAQGVINEADQRQYEEWLFHTQQLLQMQLKVLEEQIGVHRKSRKALCAKQRTAKKAGREFPEADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQQQQHSAVLAVSPSQNPRVLTKLPGQLLPAHGLQPPQAPPGGQAGGLRLPPGGMVLPGQSGGPFLNTTLAQQQQQQHSGVAGSLTGPPGSFFPGNLALRSLGPDSRLLQERQLQLQQQRMQLAQKLQQQQQQQQQQQQQQHLLGQVAIQQQQGPGVQNQALGPKPQGLLPPSNHQGLLVQQLSPQQSQGSQGLLGPAQVTVLQQQQQQQQHSGALGPQGPHRQVLMTQSRVLSSPQLAQQGHSLMGHRLLTAQQQQQQQQQQQQQQQQQQQQQQQQQGSMTGLSQLQQGMMSHGGQPKMSAQALGSLQQQQQQLQQQQMLQQQQLQQQQQQLQQQQQQQQLQQQQQQQLQLQQQQQQQQQHLQHQQQQQQQLQQQQQLQQQQQQQLHLQQQLHQQQQLQLQQQQMGLLNQNRTLLSPQQQQQQQQQQQQQQQQQQQQQQQQQQVTLGPGLPVKPLQHFSSSGALGPTLLLTGKEQNNAETALPSEVTEGPSTHQGGPPAVGTAPEPMSVEPGEVKPSISGDSQLLLVQSQAQSQATSVQLQPPLRLPGQPQPQVNLLHTAGGGSHGQQLGSGSSSESPAVPHLLAQPSVSLGEQPGPMAQNLLGSQQPLGLDRPIQNNTGSQPPKSGPAPQSGQGPPGAGVMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPFQEPGTQPSPLQGLLGCQPQPGGFSVSQTGPLQELGAGSRPQGPPRLPVPQGALSTGPVLGPAHPTPPPSSPQEPKRPSQLPSPSAQLTPTHPGTPKPQGPALELPPGRVSPAAAQLADTFFGKGLGPWDPSDNLTEAQKPEQSSLVPGHLDQVNGQVVHEPSQLSIKQEPREEPCALGAQTVKREANGEPAGAPGTSNHLLLAGSRSEAGHLLLQKLLRAKNVQLGAGRGPEGLRAEINGHIDSKLSGLEQKLQGTSSNKEDAATRKPLPAKPKRVQKTSDRLPSSRKKLRKEDGVRANEALLKQLKQELSQLPLTEPTITANFSLFAPFGSGCLVSGQSQLRGAFGSGALHTGPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVNGVTPSDELGERPKDTASAQDSEGALRDAAEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRFPQLGSGRWEQDNRALSPVIPIIPRTGIPVFPDTKPYGVLDLEVPGKLPATAWEKGKGSEVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPNSYEVLFPDGPARAGLEPKKGEAEGPGGKEKGLSGKGPDTGPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPSIQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPAEPMVELQAERPAEPPIPSPLPLASSPESARPKPRARPPEESEDSRPPRLKKWKGVRWKRLRLLLTIQKGSGHQEDEREVAEFMEQFGTALRPSKVPRDNRRCCFCHEEGDGATDGPARLLNLDLDLWVHLNCALWSTEVYETQGGALMNVEVALHRGLLTKCSLCQRTGATSSCNRMRCPNVYHFACAIRAKCMFFKDKTMLCPVHKIKGPCEQELSSFAVFRRVYIERDEVKQIASIIQRGERLHMFRVGGLVFHAIGQLLPHQMADFHSATALYPVGYEATRIYWSLRTNNRRCCYRCSISENNGRPEFVIKVIEQGLEDLVFTDASPQAVWNRIIEPVAAMRKEADMLRLFPEYLKGEELFGLTVHAVLRIAESLPGVESCQNYLFRYGRHPLMELPLMINPTGCARSEPKILTHYKRPHTLNSTSMSKAYQSTFTGETNTPYSKQFVHSKSSQYRRLRTEWKNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNEHVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQHKIPCHCGAWNCRKWMN
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 1001 |
|
|
||
| 2359 |
|
|||
| 2398 |
|
|
||
| 2528 |
|
|
||
| 2695 |
|
|||
| 2738 |
|
|
||
| 2833 |
|
|
||
| 3140 |
|
|||
| 3141 |
|
|||
| 3185 |
|
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Epigenetic regulation of gene expression by MLL3 and MLL4 complexes | Mus musculus |
| Formation of WDR5-containing histone-modifying complexes | Mus musculus |
| Formation of the beta-catenin:TCF transactivating complex | Mus musculus |
| PKMTs methylate histone lysines | Mus musculus |
| RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | Mus musculus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060473 | Kabuki syndrome |
