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MIRAGE
Proprotein convertase subtilisin/kexin type 4
Summary
- UniProt ID
- Q6UW60
- Gene Symbol
-
- PC4
- PCSK4
- UNQ2757/PRO6496
- Gene ID
- 54760
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Alternative splicing
- Cleavage on pair of basic residues
- Cytoplasmic vesicle
- Glycoprotein
- Proteomics identification
- Reference proteome
- Serine protease
- Signal
- Transmembrane helix
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| Golgi membrane |
| trans-Golgi network |
| acrosomal vesicle |
| acrosomal membrane |
| GO Term |
|---|
| protein processing |
| reproductive process |
| sperm capacitation |
| binding of sperm to zona pellucida |
| acrosome reaction |
| fertilization |
| peptide hormone processing |
| GO Term |
|---|
| serine-type endopeptidase activity |
Sequence
MRPAPIALWLRLVLALALVRPRAVGWAPVRAPIYVSSWAVQVSQGNREVERLARKFGFVNLGPIFPDGQYFHLRHRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTLQRRVKRSVVVPTDPWFSKQWYMNSEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVRMLDGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGVATDPQIVTTDLHHGCTDQHTGTSASAPLAAGMIALALEANPFLTWRDMQHLVVRASKPAHLQAEDWRTNGVGRQVSHHYGYGLLDAGLLVDTARTWLPTQPQRKCAVRVQSRPTPILPLIYIRENVSACAGLHNSIRSLEHVQAQLTLSYSRRGDLEISLTSPMGTRSTLVAIRPLDVSTEGYNNWVFMSTHFWDENPQGVWTLGLENKGYYFNTGTLYRYTLLLYGTAEDMTARPTGPQVTSSACVQRDTEGLCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRGGSPRDCTSCPPSSTLDQQQGSCMGPTTPDSRPRLRAAACPHHRCPASAMVLSLLAVTLGGPVLCGMSMDLPLYAWLSRARATPTKPQVWLPAGT
Glycosylation Sites
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050861 | colorectal adenocarcinoma |
