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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
A disintegrin and metalloproteinase with thrombospondin motifs 13
Summary
- UniProt ID
- Q76LX8
- Gene Symbol
-
- ADAMTS13
- C9orf8
- Organism
- Homo sapiens (human)
External Links
- GlycoProtDB
- GPDB0012304
- GlyConnect
- GlyGen
- Q76LX8
- PubChem
- Q76LX8
- The Human Metabolome Database
- HMDBP07465
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Blood coagulation
- Calcium
- Cleavage on pair of basic residues
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Metal-binding
- Metalloprotease
- Reference proteome
- Repeat
- Secreted
- Signal
- Zinc
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| proteolysis |
| blood coagulation |
| glycoprotein metabolic process |
| response to toxic substance |
| response to amine |
| protein catabolic process |
| protein processing |
| platelet activation |
| extracellular matrix organization |
| response to potassium ion |
| GO Term |
|---|
| extracellular matrix |
| endoplasmic reticulum lumen |
| cell surface |
| extracellular region |
| extracellular space |
| GO Term |
|---|
| calcium ion binding |
| zinc ion binding |
| metalloendopeptidase activity |
| integrin binding |
| metallopeptidase activity |
Sequence
MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRPPSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSLVPHEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQHLEPTGTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDMTFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATSNAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWESESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 142 | N-linked (GlcNAc...) asparagine |
|
||
| 146 | N-linked (GlcNAc...) asparagine |
|
||
| 387 | C-linked (Man) tryptophan |
|
||
| 399 | O-linked (Fuc...) serine |
|
||
| 552 | N-linked (GlcNAc...) asparagine | |||
| 579 | N-linked (GlcNAc...) asparagine |
|
||
| 614 | N-linked (GlcNAc...) asparagine | |||
| 667 | N-linked (GlcNAc...) (complex) asparagine |
|
||
| 698 | O-linked (Fuc...) serine |
|
||
| 707 | N-linked (GlcNAc...) (complex) asparagine |
G06356OH
G74728JK
G33791AF
G47518TP
G37881RL
G48414YA
G22310AV
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Defective B3GALTL causes PpS | Homo sapiens |
| Defective VWF cleavage by ADAMTS13 variant | Homo sapiens |
| Enhanced cleavage of VWF variant by ADAMTS13 | Homo sapiens |
| O-glycosylation of TSR domain-containing proteins | Homo sapiens |
| Platelet Adhesion to exposed collagen | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
