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MIRAGE
Sodium-dependent dopamine transporter
Summary
- UniProt ID
- Q7K4Y6
- Gene Symbol
-
- CG8380
- DAT
- fmn
- Gene ID
- 36849
- Organism
- Drosophila melanogaster (fruit fly)
Annotation
- Keyword
-
- 3D-structure
- Cell membrane
- Disulfide bond
- Glycoprotein
- Metal-binding
- Neurotransmitter transport
- Reference proteome
- Sodium
- Symport
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| plasma membrane |
| axon |
| neuronal cell body membrane |
| presynaptic membrane |
| GO Term |
|---|
| dopamine:sodium symporter activity |
| cocaine binding |
| metal ion binding |
Sequence
MSPTGHISKSKTPTPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRDQQSMAMVLNGVTTEVTVVRLTDTETAKEPVDV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 141 | N-linked (GlcNAc...) asparagine; atypical |
|
||
| 164 | N-linked (GlcNAc...) asparagine |
|
||
| 173 | N-linked (GlcNAc...) asparagine |
|
||
| 182 | N-linked (GlcNAc...) asparagine |
|
||
| 188 | N-linked (GlcNAc...) asparagine |
|
||
| 193 | N-linked (GlcNAc...) asparagine |
|
||
| 224 | N-linked (GlcNAc...) asparagine |
|
||
| 300 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Clearance of dopamine | Drosophila melanogaster |
| Na+/Cl- dependent neurotransmitter transporters | Drosophila melanogaster |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060041 | autism spectrum disorder | |
| DOID:0070489 | classic dopamine transporter deficiency syndrome | |
| DOID:1094 | attention deficit hyperactivity disorder |
