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Otoancorin
Summary
- UniProt ID
- Q7RTW8
- Gene Symbol
-
- OTOA
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Alternative splicing
- Cell membrane
- Extracellular matrix
- GPI-anchor
- Hearing
- Non-syndromic deafness
- Reference proteome
- Signal
- Gene Ontology (GO)
| GO Term |
|---|
| sensory perception of sound |
| transmission of nerve impulse |
| cell-matrix adhesion |
| GO Term |
|---|
| extracellular region |
| plasma membrane |
| apical plasma membrane |
| cell surface |
| side of membrane |
Sequence
MSQEPTTYSLFLFLFLSHGVSSYTVPNSRQDLHPLLQNMAEEIIDGSYLNALLDLIQFQSSHVWTDDLSHRVLAYLNSRNVAFTIPSLQAAVENHLEQRLHQPQKLLEDLRKTDAQQFRTAMKCLLEDKKDGLDLKDIIIDLGEIRERALQSPGVNRSLFLITLERCFQMLNSLECVEILGKVLRGSSGSFLQPDITERLPRDLREDAFKNLSAVFKDLYDKTSAHSQRALYSWMTGILQTSSNATDDSASWVSAEHLWVLGRYMVHLSFEEITKISPIEIGLFISYDNATKQLDMVYDITPELAQAFLERISSSNFNMRNTSTIHRQAHELWALEPFPKMLGLLVCFYNDLELLDATVAQVLLYQMIKCSHLRGFQAGVQKLKAELLDIAMENQTLNETLGSLSDAVVGLTYSQLESLSPEAVHGAISTLNQVSGWAKSQVIILSAKYLAHEKVLSFYNVSQMGALLAGVSTQAFCSMKRKDISQVLRSAVSQYVSDLSPAQQQGILSKMVQAEDTAPGIVEIQGAFFKEVSLFDLRRQPGFNSTVLKDKELGRSQALFLYELLLKTTRRPEELLSAGQLVKGVTCSHIDAMSTDFFLAHFQDFQNNFALLSPYQVNCLAWKYWEVSRLSMPPFLLAALPARYLASVPASQCVPFLISLGKSWLDSLVLDSHKKTSVLRKVQQCLDDSIADEYTVDIMGNLLCHLPAAIIDRGISPRAWATALHGLRDCPDLNPEQKAAVRLKLLGQYGLPQHWTAETTKDLGPFLVLFSGDELSSIATKFPEILLQAASKMARTLPTKEFLWAVFQSVRNSSDKIPSYDPMPGCHGVVAPSSDDIFKLAEANACWALEDLRCMEEDTFIRTVELLGAVQGFSRPQLMTLKEKAIQVWDMPSYWREHHIVSLGRIALALNESELEQLDLSSIDTVASLSWQTEWTPGQAESILQGYLDDSGYSIQDLKSFHLVGLGATLCAINITEIPLIKISEFRVVVARIGTLLCSTHVLAEFKRKAEVVFGDPTEWTSSVLQELGTIAAGLTKAELRMLDKDLMPYFQPSAIKCLPDEIFKELSAEQIASLGPENAAAVTHAQRRRLSPLQLQSLQQALDGAKTHSWQDAPASAGPTRTSSSRSPAGALQSWGLWLGCPLLVLMAKLLW
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 156 | N-linked (GlcNAc...) asparagine |
|
||
| 211 | N-linked (GlcNAc...) (complex) asparagine |
|
||
| 244 | N-linked (GlcNAc...) asparagine |
|
||
| 289 | N-linked (GlcNAc...) asparagine |
|
||
| 321 | N-linked (GlcNAc...) asparagine |
|
||
| 394 | N-linked (GlcNAc...) asparagine |
|
||
| 398 | N-linked (GlcNAc...) asparagine |
|
||
| 460 | N-linked (GlcNAc...) asparagine |
|
||
| 544 | N-linked (GlcNAc...) asparagine |
|
||
| 812 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Post-translational modification: synthesis of GPI-anchored proteins | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050564 | autosomal dominant nonsyndromic deafness | |
| DOID:0050565 | autosomal recessive nonsyndromic deafness | |
| DOID:0050566 | X-linked nonsyndromic deafness | |
| DOID:0050811 | congenital adrenal hyperplasia | |
| DOID:0060295 | complement component 2 deficiency | |
| DOID:0060574 | von Willebrand's disease 2 | |
| DOID:0060690 | autosomal dominant auditory neuropathy 1 | |
| DOID:0110462 | autosomal recessive nonsyndromic deafness 101 | |
| DOID:0110463 | autosomal recessive nonsyndromic deafness 102 | |
| DOID:0110464 | autosomal recessive nonsyndromic deafness 103 |
