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Proprotein convertase subtilisin/kexin type 9

Summary

UniProt ID

Q80W65

Gene Symbol

Pcsk9
Narc1

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0006067
PubChem: Q80W65

Annotation

Keyword

Apoptosis
Autocatalytic cleavage
Calcium
Cholesterol metabolism
Cytoplasm
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Lysosome
Phosphoprotein
Reference proteome
Secreted
Serine protease
Signal
Sulfation
Zymogen

Gene Ontology (GO)

Displaying entries **1 - 10** of 26 in total

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GO Term
triglyceride metabolic process
cellular response to starvation
negative regulation of low-density lipoprotein particle clearance
low-density lipoprotein receptor particle metabolic process
low-density lipoprotein particle receptor catabolic process
regulation of low-density lipoprotein particle receptor catabolic process
positive regulation of low-density lipoprotein particle receptor catabolic process
negative regulation of receptor-mediated endocytosis involved in cholesterol transport
apoptotic process
lysosomal transport

Displaying entries **1 - 10** of 15 in total

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GO Term
endoplasmic reticulum
early endosome
late endosome
endoplasmic reticulum lumen
cell surface
COPII-coated ER to Golgi transport vesicle
perinuclear region of cytoplasm
cytoplasm
lysosome
Golgi apparatus

Displaying **all 10** entries
GO Term
low-density lipoprotein particle binding
apolipoprotein receptor binding
protein self-association
very-low-density lipoprotein particle receptor binding
signaling receptor inhibitor activity
apolipoprotein binding
low-density lipoprotein particle receptor binding
sodium channel inhibitor activity
very-low-density lipoprotein particle binding
serine-type endopeptidase activity

Annotation information from UniProt.

Sequence

MGTHCSAWLRWPLLPLLPPLLLLLLLLCPTGAGAQDEDGDYEELMLALPSQEDGLADEAAHVATATFRRCSKEAWRLPGTYIVVLMEETQRLQIEQTAHRLQTRAARRGYVIKVLHIFYDLFPGFLVKMSSDLLGLALKLPHVEYIEEDSFVFAQSIPWNLERIIPAWHQTEEDRSPDGSSQVEVYLLDTSIQGAHREIEGRVTITDFNSVPEEDGTRFHRQASKCDSHGTHLAGVVSGRDAGVAKGTSLHSLRVLNCQGKGTVSGTLIGLEFIRKSQLIQPSGPLVVLLPLAGGYSRILNAACRHLARTGVVLVAAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGKDIIGASSDCSTCFMSQSGTSQAAAHVAGIVARMLSREPTLTLAELRQRLIHFSTKDVINMAWFPEDQQVLTPNLVATLPPSTHETGGQLLCRTVWSAHSGPTRTATATARCAPEEELLSCSSFSRSGRRRGDWIEAIGGQQVCKALNAFGGEGVYAVARCCLVPRANCSIHNTPAARAGLETHVHCHQKDHVLTGCSFHWEVEDLSVRRQPALRSRRQPGQCVGHQAASVYASCCHAPGLECKIKEHGISGPSEQVTVACEAGWTLTGCNVLPGASLTLGAYSVDNLCVARVHDTARADRTSGEATVAAAICCRSRPSAKASWVQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
536	N-linked (GlcNAc...) asparagine			GlycoProtDB UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
LDL clearance	Mus musculus
Post-translational protein phosphorylation	Mus musculus
Regulation of IGF Activity by IGFBP	Mus musculus
VLDLR internalisation and degradation	Mus musculus