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Stimulator of interferon genes protein

Summary

UniProt ID

Q86WV6

Gene Symbol

STING1
ERIS
MITA
STING
TMEM173

Organism

Homo sapiens (human)

External Links

PubChem: Q86WV6
The Human Metabolome Database: HMDBP12695
The O-GlcNAc Database: Q86WV6
RaftProt: Q86WV6

Annotation

Keyword

3D-structure
Autophagy
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Disease variant
Endoplasmic reticulum
Golgi apparatus
Host-virus interaction
Innate immunity
Ion channel
Isopeptide bond
Mitochondrion outer membrane
Nucleotide-binding
Palmitate
Phosphoprotein
Reference proteome
Transmembrane helix
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 23 in total

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GO Term
positive regulation of transcription by RNA polymerase II
positive regulation of DNA-binding transcription factor activity
activation of innate immune response
pattern recognition receptor signaling pathway
positive regulation of defense response to virus by host
cytoplasmic pattern recognition receptor signaling pathway
defense response to virus
positive regulation of interferon-beta production
cellular response to interferon-beta
protein complex oligomerization

Displaying entries **1 - 10** of 16 in total

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GO Term
Golgi membrane
autophagosome membrane
autophagosome
plasma membrane
secretory granule membrane
cytoplasmic vesicle membrane
serine/threonine protein kinase complex
STING complex
peroxisome
cytosol

Displaying **all 9** entries
GO Term
identical protein binding
protein homodimerization activity
proton channel activity
signaling adaptor activity
cyclic-di-GMP binding
protein kinase binding
RNA polymerase II-specific DNA-binding transcription factor binding
2',3'-cyclic GMP-AMP binding
ubiquitin protein ligase binding

Annotation information from UniProt.

Sequence

MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
229			G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
IRF3-mediated induction of type I IFN	Homo sapiens
Neutrophil degranulation	Homo sapiens
Regulation of innate immune responses to cytosolic DNA	Homo sapiens
SARS-CoV-1 activates/modulates innate immune responses	Homo sapiens
SARS-CoV-2 activates/modulates innate and adaptive immune responses	Homo sapiens
STAT6-mediated induction of chemokines	Homo sapiens
STING mediated induction of host immune responses	Homo sapiens